CMAC Research Case Studies

Welcome to the CMAC Case Studies page. Here, you can explore a diverse collection of real-world examples showcasing the application of advanced manufacturing research, training, and continuous processing technologies in the medical sector.

Use the filter options to tailor your search according to specific areas of interest, technology types, or project outcomes, enabling you to find insights relevant to your needs and challenges. Discover how CMAC’s expertise drives innovation and enhances medicine manufacturing globally.

Featured
Digital Pharmaceutical Process Design: Faster, Cost Effective and Sustainable Delivery of Quality Drug Substance
Digital Pharmaceutical Process Design: Faster, Cost Effective and Sustainable Delivery of Quality Drug Substance

Through digital-first process design, CMAC researchers decrease the material required for API development by an order of magnitude.

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Featured
Digital Pharmaceutical Process Design: Faster, Cost Effective and Sustainable Delivery of Quality Drug Substance
Process Design
Digital Pharmaceutical Process Design: Faster, Cost Effective and Sustainable Delivery of Quality Drug Substance
Process Design

Through digital-first process design, CMAC researchers decrease the material required for API development by an order of magnitude.

Read More →
Process Design
From Lab to Clinical Development: CMAC’s Impurity Rejection Workflow
From Lab to Clinical Development: CMAC’s Impurity Rejection Workflow

Researchers at Eli Lilly & Company have successfully applied CMAC’s impurity rejection workflow in clinical development, achieving up to 100% rejection of problematic impurities.

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Knowledge Transfer Partnerships
KTPs
Knowledge Transfer Partnerships
KTPs

Model-based Digitalisation Framework Development for Continuous Manufacturing Processes

Workflows for the Application of a User-friendly Mechanistic Modelling Toolkit

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KTPs
Peptide Isolation via Spray Drying: Investigating Particle Formation and Means of Process Implementation
PhD Industrial Placements
Peptide Isolation via Spray Drying: Investigating Particle Formation and Means of Process Implementation
PhD Industrial Placements
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PhD Industrial Placements
Developing Workflows for Continuous Crystallisation
Workflows
Developing Workflows for Continuous Crystallisation
Workflows

Considerable time has been spent as part of the EPSRC CMAC CIM research campaign, designing and implementing a workflow for continuous cooling crystallisation.

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Workflows
Manufacturing Operations and Supply Chain Management Challenges in Continuous Manufacturing
Supply Chain
Manufacturing Operations and Supply Chain Management Challenges in Continuous Manufacturing
Supply Chain

This research explores possibilities to align future value network configurations and disruptive shifts in manufacturing and information technologies.

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Supply Chain
From Molecule to Lab to Plant: Computer Aided Process Design
Process Design
From Molecule to Lab to Plant: Computer Aided Process Design
Process Design

Computer Aided Process Design (CAPD) and simulation tools have been successfully implemented in the chemical and oil industries since the early 60s to accelerate development and optimise the design and operation of process.

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Process Design
Exquisite Particles: Towards predicting agglomeration in APIs
Exquisite Particles
Exquisite Particles: Towards predicting agglomeration in APIs
Exquisite Particles

Along with nucleation and growth, agglomeration is a commonly occurring process in crystallisation operations.

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Exquisite Particles
Made to Order Processing Plant
Processing Plant
Made to Order Processing Plant
Processing Plant

The “Make To Order Processing Plants” (MOPPs) project involving CMAC, CPI, AstraZeneca and led by Perceptive Engineering.

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Processing Plant
Platform Technology Development
Platform Technology
Platform Technology Development
Platform Technology

The particle engineering research group under the supervision of Prof Jan Sefcik has designed and investigated a novel continuous seed production unit.

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Platform Technology
Improved Manufacture of a Melt-Cast Explosive
Improved Manufacture
Improved Manufacture of a Melt-Cast Explosive
Improved Manufacture

In the production of many materials solid state variation is recognised as a key issue.

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Improved Manufacture
Solid State Selection Using a Novel Nucleator Coupled With Design of Experiment (DoE)
Solid State Selection
Solid State Selection Using a Novel Nucleator Coupled With Design of Experiment (DoE)
Solid State Selection

In the production of many materials solid state variation is recognised as a key issue.

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Solid State Selection