CMAC Research Case Studies

CMAC’s digital‑first process design is cutting pharmaceutical development timelines and material use by an order of magnitude while delivering high‑quality drug substance. By replacing trial‑and‑error experimentation with predictive modelling, it enables faster, more cost‑effective and sustainable manufacturing.

CMAC’s impurity rejection workflow provides industry with a systematic, material‑efficient approach to achieving high‑purity crystalline products in drug manufacturing. Successfully applied by Eli Lilly in clinical development, it enables robust control of impurity‑related CQAs and accelerates crystallisation process design.

Model-based Digitalisation Framework Development for Continuous Manufacturing Processes

Workflows for the Application of a User-friendly Mechanistic Modelling Toolkit

This collaborative CMAC–Eli Lilly project explores spray drying as a faster, scalable alternative to lyophilisation for isolating therapeutic peptides. Through targeted experimentation and advanced data capture, it delivers practical guidance for improving manufacturability and accelerating peptide drug development.

Considerable time has been spent as part of the EPSRC CMAC CIM research campaign, designing and implementing a workflow for continuous cooling crystallisation.

This research explores possibilities to align future value network configurations and disruptive shifts in manufacturing and information technologies.

Computer Aided Process Design (CAPD) and simulation tools have been successfully implemented in the chemical and oil industries since the early 60s to accelerate development and optimise the design and operation of process.

Along with nucleation and growth, agglomeration is a commonly occurring process in crystallisation operations.

The “Make To Order Processing Plants” (MOPPs) project involving CMAC, CPI, AstraZeneca and led by Perceptive Engineering.

The particle engineering research group under the supervision of Prof Jan Sefcik has designed and investigated a novel continuous seed production unit.

In the production of many materials solid state variation is recognised as a key issue.

In the production of many materials solid state variation is recognised as a key issue.