CMAC’s vision is to revolutionise the way pharmaceuticals and high value products are made. The approaches developed and adopted within CMAC have been developed through close collaboration with industry and the support of its Tier 1 partners, which includes GlaxoSmithKline, AstraZeneca, Bayer, Lilly, Novartis, Pfizer, Roche and Takeda. Established in 2011, the CMAC has a £150m funding portfolio and currently comprises more than 130 staff and researchers, including academics, post docs, and more than 30 PhD students, as well as an experienced support team.
Advanced Medicine Manufacturing Platform Project Engineer (375936)
Applications are invited for a highly motivated, enthusiastic Engineer to join the EPSRC Future Manufacturing Research Hub in Continuous Manufacturing and Advanced Crystallisation (CMAC; www.cmac.ac.uk) led by the University of Strathclyde. CMAC is a large dynamic Centre located across seven UK universities with the physical hub located at the University of Strathclyde. This role will work alongside a wider team to integrate existing equipment and sensors, apply automation and control systems, to deliver a novel MicroFactory platform for medicines manufacture. This post is initially a 12-month post with potential to extend.
The post holder will have a background in mechanical engineering, chemical engineering, electrical engineering, physical science or a related discipline, along with work based experience of equipment development, design and fabrication. Experience of modelling related to process engineering (such as computational fluid dynamics, discrete element analysis or finite element analysis) would be advantageous. Experience of control systems engineering would also be advantageous. Whilst this is a multidisciplinary role, we encourage applicants who are an expert in any one of the above areas and where appropriate, additional training and support would be provided.
You will be a hands on practitioner with the ability to design, test, modify and implement improved equipment capabilities for use in small scale manufacture of pharmaceuticals. The successful candidate will contribute significantly to the technical development of MicroFactories for pharmaceutical development and manufacturing applications.
Informal enquiries about the post can be directed to Cameron Brown, Strathclyde Chancellor’s Fellow (firstname.lastname@example.org).
Formal interviews for this post will be held in July 2021.
EPSRC Digital Pharma Production Research Associate: Machine Learning for Reactor Design & Optimisation (375865)
The Universities of Strathclyde and Nottingham are pleased to announce an EPSRC-funded partnership with GlaxoSmithKline (GSK) on the Accelerated Discovery & Development of New Medicines.
Driven by Strathclyde and Nottingham’s world-leading research expertise, and informed by GSK’s Innovation, Performance and Trust agenda, this 5-year programme will build on the existing collaborations between the three partners, to deliver a new suite of methods and approaches that tackle the major challenges in the discovery, development, and manufacture of medicines. Our vision is to enable the production of novel, transformative medicines at lower costs, with reduced waste production and shorter manufacturing times.
The programme is based around 4 Themes addressing these key research challenges:
1. Developing and applying AI and machine learning to the efficient identification of next generation medicines.
2. Designing and developing the next generation of catalysts and synthetic methods to facilitate more effective preparation of new drug-like molecules.
3. Utilising sustainable processes that can transition from grams to kilogrammes.
4. Enabling the digital manufacturing of pharmaceutical processing equipment using additive manufacturing technologies.
The partnership will not only connect research excellence between the three project partners, but will also integrate the multiple disciplines aligned with the programme through collaboration between the research Themes. These enhanced levels of connectivity will deliver new science across the pharmaceutical continuum, and lead to the faster development of transformative medicines to help people do more, feel better and live longer.
In order to deliver on this ambitious goal, over the course of the partnership we are seeking to recruit up to 10 postdoctoral Research Fellows/Associates to work in the themes above. The appointed researchers will join a partnership team comprising 23 academic scientists at Strathclyde and Nottingham, along with over 20 GSK scientists. During the course of the programme, over 50 PhD students, funded by GSK and the two partner universities, will augment the research team.
Each postdoctoral researcher will be based at one of the two academic institutions, and will work closely with scientists from GSK and the other partner university to ensure that the novel science that is developed is effectively translated into the pharmaceutical industry. As part of this, the opportunity for research secondments into the other partners will be available to all postdoctoral researchers.
Closing Date: 22nd June 2021 .... more
Process Technician in the Continuous Manufacturing and Advanced Crystallisation
Applications are invited for a Process Technician in the Continuous Manufacturing and Advanced Crystallisation (www.cmac.ac.uk) Centre at the University of Strathclyde. This post will provide maternity leave cover for a period of 8 months, with a possible extension of up to 12 months. CMAC comprises a multidisciplinary team of academics, researchers and technical staff, providing a platform for collaborative research, training and knowledge exchange in the area of advanced pharmaceutical manufacturing. This role will provide support to both equipment and projects within the CMAC Facility.
The main duties of the post will be the operational execution of projects under the guidance of senior staff. The successful candidate will be expected to utilise specialist experimental equipment associated with continuous operation and pharmaceutical crystallisation. Prior knowledge in these areas is valuable but it is anticipated that a period of intensive training will be provided. The ability to keep accurate records through our existing electronic lab notebook system and follow best practice laboratory and reporting procedures will be essential.
You can follow this link for further details: View Vacancy Details .... more
CMAC Call for Feasibility Study Proposals - DEADLINE 11th JUNE 2021
The EPSRC Future Manufacturing CMAC Research Hub is offering analytical support for projects that would benefit from surface analysis by Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). This support is available for novel short-term feasibility research projects across all scientific disciplines..... more
MIT-CMAC International Symposium on Continuous Manufacturing of Pharmaceuticals
An Integrated Ecosystem for Transforming Medicines Manufacturing
February’s meeting, jointly run between MIT and CMAC Future Manufacturing Research Hub, brought together over 350 pharmaceutical industrialists, regulators, policy makers and academics from more than 22 countries and 142 organisations to inform strategies to grow medicines manufacturing in the UK and internationally, through accelerating the adoption of advanced manufacturing and digital technologies..... more
Advanced Characterisation using Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS)
ToF-SIMS has recently been incorporated into the advanced materials characterisation services provided by the CMAC National Facility with a view to providing analytical services to the wider academic community. The ToF-SIMS service is a central part of the long-term collaboration between CMAC and NPL, and benefits from the joint expertise and knowledge of both institutions. .... more