Levelling up in the lab: CMAC’s new VR game sparks STEM curiosity
CMAC is levelling up STEM engagement with an immersive VR game that brings digital medicines manufacturing to life for young learners. Developed with The Glasgow School of Art, the experience transforms complex lab science into playful, hands‑on missions that inspire curiosity, build skills, and spark future career ambitions.
ESTAN: A User-Friendly Toolbox for Improving Model Estimability and Predictive Performance
ESTAN is a user‑friendly modelling toolbox developed by Loughborough University in collaboration with CMAC. It simplifies complex sensitivity and estimability analyses, helping users build mathematical models and digital twins with stronger predictive performance.
Digital Pharmaceutical Process Design: Faster, Cost Effective and Sustainable Delivery of Quality Drug Substance
CMAC’s digital‑first process design is cutting pharmaceutical development timelines and material use by an order of magnitude while delivering high‑quality drug substance. By replacing trial‑and‑error experimentation with predictive modelling, it enables faster, more cost‑effective and sustainable manufacturing.
From Lab to Clinical Development: CMAC’s Impurity Rejection Workflow
CMAC’s impurity rejection workflow provides industry with a systematic, material‑efficient approach to achieving high‑purity crystalline products in drug manufacturing. Successfully applied by Eli Lilly in clinical development, it enables robust control of impurity‑related CQAs and accelerates crystallisation process design.
Knowledge Transfer Partnerships
Model-based Digitalisation Framework Development for Continuous Manufacturing Processes
Workflows for the Application of a User-friendly Mechanistic Modelling Toolkit
Peptide Isolation via Spray Drying: Investigating Particle Formation and Means of Process Implementation
This collaborative CMAC–Eli Lilly project explores spray drying as a faster, scalable alternative to lyophilisation for isolating therapeutic peptides. Through targeted experimentation and advanced data capture, it delivers practical guidance for improving manufacturability and accelerating peptide drug development.
Developing Workflows for Continuous Crystallisation
Considerable time has been spent as part of the EPSRC CMAC CIM research campaign, designing and implementing a workflow for continuous cooling crystallisation.
Manufacturing Operations and Supply Chain Management Challenges in Continuous Manufacturing
This research explores possibilities to align future value network configurations and disruptive shifts in manufacturing and information technologies.
From Molecule to Lab to Plant: Computer Aided Process Design
Computer Aided Process Design (CAPD) and simulation tools have been successfully implemented in the chemical and oil industries since the early 60s to accelerate development and optimise the design and operation of process.
Exquisite Particles: Towards predicting agglomeration in APIs
Along with nucleation and growth, agglomeration is a commonly occurring process in crystallisation operations.
Made to Order Processing Plant
The “Make To Order Processing Plants” (MOPPs) project involving CMAC, CPI, AstraZeneca and led by Perceptive Engineering.
Platform Technology Development
The particle engineering research group under the supervision of Prof Jan Sefcik has designed and investigated a novel continuous seed production unit.
Improved Manufacture of a Melt-Cast Explosive
In the production of many materials solid state variation is recognised as a key issue.
Solid State Selection Using a Novel Nucleator Coupled With Design of Experiment (DoE)
In the production of many materials solid state variation is recognised as a key issue.