Vacancies


202122DEC

CMAC National Facility Co-ordinator (382021)

The EPSRC Continuous Manufacturing and Advanced Crystallisation Future Manufacturing Research Hub (www.cmac.ac.uk) is a national research centre led by the University of Strathclyde. It comprises a large, multidisciplinary team of academics and researchers located across seven Universities within the UK. The Hub provides a platform for collaborative research, training and knowledge exchange in advanced pharmaceutical manufacturing to make better, more affordable medicines for the future. The Hub also has a large and vibrant programme with key Industry partners  AZ, Chiesi, Lilly, Pfizer, Roche, Takeda and UCB, as well as technology companies. This world-class facility has been established through support from a £33.4M UK RPIF award plus major support from the Wolfson Foundation, EPSRC and the £100M University of Strathclyde Technology & Innovation Centre (TIC). The facility houses a comprehensive suite of high-value, state-of-the-art equipment. In addition, the facility is enhancing our ability to support effective collaboration by co-locating researchers from across CMAC and our partners to work together. The facility team provides comprehensive support across the varied and complex equipment base. This team supports a growing user community to access the suite of over 200 items of equipment within a multi-project, multi-user context both academic and industrial. Applications are invited from experienced administrators seeking a challenging role within the National Facility. The successful applicant will provide organisational and administrative support to the National Facility team including co-ordinating meetings with both academic and industrial clients, diary management, invoicing, reporting, marketing, social media and supporting the Technical Operations Manager with electronic laboratory management systems. Candidates must have excellent IT, communication and interpersonal skills with the ability to organise and prioritise a busy workload using their own initiative. Experience of working with an internal financial management system (FMS) and/or previous experience of research administration within a university environment would be advantageous. The post is initially for 24 months, but an extension beyond this period is anticipated.

Closing Date: 14/01/2022

Click here for full details

202129NOV

X-ray PDF Applications Scientist (KTP Associate) (411261)

The Continuous Manufacturing and Advanced Crystallisation (CMAC, www.cmac.ac.uk) hub at the University of Strathclyde in partnership with AstraZeneca is seeking to appoint a Knowledge Transfer Partnership (KTP) Associate in the area of X-ray Pair Distribution Function (PDF) analysis. In particular, the role is focussed on the application of PDF to AstraZeneca materials and the focus of the role is on developing approaches for routine sample preparation, laboratory and synchrotron data collection, PDF analysis, reporting and development of training material to enable and support users to implement successfully this powerful analytical method.

 

AstraZeneca is a leading global biopharmaceutical company with a passion for science (https://www.astrazeneca.com). This includes the application of leading edge analytical methods within development projects to characterise materials This position will be based in AstraZeneca’s Pharmaceutical Research & Development function in Macclesfield.

 

The post is on a fixed term basis for a period of 24 months with a proposed start date of February 2022. The project is part of the Knowledge Transfer Partnership (KTP) programme that aims to help businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills that reside within the UK knowledge base. Successful Knowledge Transfer Partnership projects are funded by UK Research and Innovation through Innovate UK and are part of the government’s Industrial Strategy. To find out how KTP works and the vital role you will play if you successfully secure a KTP Associate position please visit: www.ktpws.org.uk.

 

You will have a PhD in a chemistry, materials science, physics, pharmaceutical science or a related discipline with appropriate experience in a collaborative research environment with knowledge in the area of pharmaceutical materials, X-ray scattering, data analysis and solid form characterisation. Practical experience of working with amorphous materials and in the use of laboratory X-ray and/or synchrotron sources and in the analysis and interpretation of data will be advantageous.

 

You must have excellent verbal and written communications skills with the ability to write clearly and succinctly. You must also be able to work as a member of a team, as well as demonstrate successful track record of research achievement. You should be able to independently develop new concepts in your research, have excellent organisational skills, initiative, and the ability to pay close attention to details. In addition to the KTP core development training, you will have a dedicated training budget of £4,000 to further support your career development. Location of this role, the Associate will be expected to work mostly at AstraZeneca’s Research & Development Campus in Macclesfield, however will be required to work at the University of Strathclyde for a period of time.

 

Informal enquiries about the post can be directed to Prof Alastair Florence, (alastair.florence@strath.ac.uk).  

 Closing Date: 31/01/2022

Click here for full details


202129NOV

Industry Key Account Officer (413255)

 
 

Salary range : £28,756 - £32,344

FTE : 1.0

Term : Fixed (24 months)

Closing date : 31/01/2022

 

The Continuous Manufacturing and Advanced Crystallisation (CMAC) Hub is a world-class centre of excellence for advanced pharmaceutical manufacturing research and training. As an EPSRC Future Manufacturing Research Hub, led by the University of Strathclyde we work in close collaboration with a number of spokes at leading UK academic institutions (Bath, Cambridge, Imperial College, Leeds, Loughborough, Sheffield) and linking with international centres in the US, Europe and Far East. Working in partnership with industry, CMAC’s purpose is to transform the development and manufacture of medicines through advanced design and manufacturing technologies including the development of Digital Twins and MicroFactories. The four key pillars of CMAC’s program are to: deliver high quality manufacturing research; develop the workforce of the future through skills development and training; to drive effective translation of research into industry and, to continue to develop our world leading facilities and lab of the future infrastructure. 

 

This post offers an exciting opportunity for an experienced administrator/coordinator, ideally with experience in a scientific area. The post holder will be the key contact between CMAC and its industry partners, and will work closely with the Technical Translation Manager and Business Development & Translation Manager, and other senior management to support industry partner engagement with the Centre to develop and sustain long-term relationships. 
Responsibilities include: key contact with industry partners (e.g. liaise, collate, and organise key milestones and deliverables, and KPIs), create detailed plans designed to attain predetermined goals and quotas, present and report results and emerging opportunities, design and produce communication material, and provide organisational and administrative support for the CMAC Directors. 

 

The post holder will work with the CMAC industry team on strategic issues relating to development, management and delivery of the Centre’s collaborative programmes with industry partners. They will also co-ordinate meetings and workshops and lead preparation of relevant materials and reports. 

 

Candidates must have excellent IT, communication and interpersonal skills with the ability to organise and prioritise a busy workload using initiative. A relevant technical degree and experience of research administration in a university or company environment is desired. Some travel to events in UK and worldwide is likely with this role.
This is an exciting and challenging position which will provide an ambitious and committed candidate with valuable experience within an International leading Research Centre providing a multi-disciplinary, multi-site university and industry collaborative research environment. Though the position is initially fixed term, there may be opportunity for extension.  
 
Closing Date: 31/01/2022

Informal enquiries about the post can be directed to Massimo Bresciani, CMAC Industry Director (massimo.bresciani@strath.ac.uk).

Click here for full details


202129JUL

PhD position - Resource-sparing direct compression formulation optimiser to accelerate medicine development

The PhD Training Opportunity at CMAC

This is an exciting opportunity to join a dynamic research team based at the University of Strathclyde and working closely with GlaxoSmithKline and collaborators within the Continuous Manufacturing and Advanced Crystallisation Hub (CMAC), gain experience of a range of techniques as part of your research. This project is also supported through The Data Lab which will provide world-class training in data science. 

Researchers working on CMAC projects have a great opportunity to conduct cutting-edge research in world class facilities, explore academic and industrial collaborations, experience working in industry through placements, and receive multidisciplinary training and mentoring that will help them develop into well-rounded professionals. The structure of a PhD project with CMAC includes a period of initial training and familiarisation with the Hub’s activities, participation in summer schools, outreach events, mentoring schemes, and supervision from academic and industrial advisers. 

Information on Application Process

To apply for this project, you should have a background in chemical engineering, chemistry, physics, pharmaceutical science, material science, mechanical engineering, or similar. You will need to have a passion for research, multidisciplinary collaboration, and collaboration with industrial stakeholders. 

The offered studentship covers home tuition fees, research/training costs, and provides a stipend for 4 years. Candidates eligible for home fees are UK or Irish nationals, applicants with a settled or pre-settled status in the UK under the EU Settlement Scheme, and applicants with indefinite leave to remain in the UK. We also welcome applications from EU or international candidates who can provide evidence of their ability to fund the fee difference.

Primary Supervisor: Dr Daniel Markl

Additional Supervisor/s: Dr John Robertson, Dr Richard Elkes (GlaxoSmithKline)

Contact Details: Applicants can express their interest for this project or ask any questions by emailing  and attaching their CV.

Closing Date:23/08/2021


202111MAY

PhD position - Data-driven approaches for in-line monitoring of particle attributes in chemical and pharmaceutical manufacturing processes


follow this link for further details:
https://www.findaphd.com/phds/project/data-driven-approaches-for-in-line-monitoring-of-particle-attributes-in-chemical-and-pharmaceutical-manufacturing-processes/?p121432


202111MAY

PhD position-Predicting drug solubility in different solvents using molecular simulation and machine learning

Follow this link for further details:
https://www.findaphd.com/phds/project/predicting-drug-solubility-in-different-solvents-using-molecular-simulation-and-machine-learning/?p84053


Industry Vacancies

Eli Lilly Vacancy: Synthetic Molecule Design and Development Automated Crystallisation Development

Synthetic Molecule Design and Development (SMDD) is an innovation-focused organization within Eli Lilly and Company. SMDD is involved in key activities for the development of synthetic active pharmaceutical ingredients and drug products from pre-clinical phases through commercialization.

Our dynamic group is made up of chemists, pharmaceutical scientists, analytical chemists, and engineers. We strive to identify, develop and apply ground-breaking technologies to deliver maximum benefit to our patients. SMDD delivers on these responsibilities by recognizing diverse talent and cultures are necessary to bring the next generation of life changing medicines to patients.

Our team is looking for an ambitious post-doctoral scientist with strong research and communication skills to contribute to highly visible research projects. You will reside in the Particle Design Laboratory (PDL) within SMDD, which serves as a core competency center for particle and crystallization process design. Your work will improve our strategies for solid-form isolation of small molecule APIs through both basic and applied research.
>>> more

AstraZeneca Vacancy: Associate Principal Scientist Ė Process Engineering

Location: Macclesfield

An exciting opportunity has arisen for an appropriately experienced Associate Principal Scientist - Process Engineering to join our Oral Product Development team.

At Oral Product Development (OPD) in Macclesfield, we focus on the design and development of commercial products and processes, contribute to new product introductions and to the continuous improvement of launched products. You will join a vibrant team that is working on the next generation of medicines and play a key role in the development of new medicinal products.

The role
As an Associate Principal Scientist in Process Engineering, you will be a key member of both our process engineering and wider pharmaceutics communities, responsible for delivering the manufacturing process understanding to progress the development of life-changing medicines within a dynamic team environment. We will rely on you to bring a strong understanding of drug product manufacturing processes to our oral solid dosage products, keeping both patients and long term manufacturing performance in mind.
>>> more

Computational Materials Science Leader - Pfizer ( 4834199 )

The Drug Product Design department is a global R&D organization that develops new medicines for unmet medical needs. Digital design is a key part of the science and technology strategy for the department. We are actively seeking to hire creative scientists and engineers with computational chemistry expertise. The Computational Materials Science Leader will apply state-of-the-art computational chemistry and crystallographic tools to calculate the solid-state properties of Pfizer molecules to streamline experimental efforts and to design better medicines. This will enable Pfizer project teams to de-risk their programs and to move rapidly into clinical studies with the ultimate goal of commercialization. The role is highly collaborative, requiring extensive work on multi-disciplinary project teams. With this role there is also a significant opportunity to publish peer reviewed research and to develop novel computational methods, addressing gaps in our current knowledge and capabilities.



Responsibilities

Paint a compelling vision for the future direction of computational modelling as an enabler of drug product development
Provide leadership to a community of computational chemists and materials scientists to help deliver Pfizerís new product portfolio
Apply established computational approaches to portfolio to drive decision making and experimental design
Train and mentor colleagues in computational techniques
Collaborate with both subject matter experts (SMEs) and non-SMEs to drive the adoption of computational tools and approaches
Bringing external scientific and computational advances to bear on day-to-day problem solving


Basic Qualifications

Candidate is likely to have a PhD in Chemistry, Physics, Materials Science or Engineering, or a closely related discipline with 5-10 years of post graduate experience, or a Masterís degree in these disciplines with 10-15 years of relevant experience in industry or academia.

Advanced programing and scripting skills (such as Python, R, Jupyter Notebook, GitHub, etc)
Strong coding skills in a scientific programming language (such as C/C++, Python, Perl) with demonstrated evidence of coding expertise and data analysis.
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
view full vacancy details/apply here
>>> more

Senior Scientist - Computational Materials Science - Pfizer ( 4834200 )

The computational senior scientist will utilize state-of-the-art computational chemistry and crystallographic tools to calculate the solid-state properties of Pfizer molecules so that their properties and performance can be predicted. This will enable Pfizer project teams to de-risk their programs and move rapidly to clinical studies in patients and ultimately to commercialization. The role is highly collaborative and requires extensive work on multi-disciplinary project teams. There is also a significant role to be played in the development of new computational methods to address gaps in current knowledge / capabilities.

Responsibilities

Apply state-of-the-art computational approaches to predict the properties and performance of crystalline and amorphous drug substance samples.
Use computational techniques (including matched molecular pair analysis, full interaction maps, solvation energy calculations and hydrogen bonding propensity analyses) to compare and rank new molecules against existing three-dimensional crystal structures (such as those in the Cambridge Crystallographic Database (CSD)).
Conduct Crystal Structure Prediction (CSP) calculations and free energy calculations for polymorph stability ranking.
Make recommendations for targeted crystallization experiments and/or modifications to the molecular structure to provide enhanced physical properties and stability of the material in the solid state.
Oversee the work of external partners conducting computational analyses, and provide tactical guidance and critical analysis of their work.
Solve scientific problems using contemporary solid state computational techniques.
Participate on multidisciplinary project teams, and collaborate with colleagues to define and recommend screening and characterization strategies according to project timelines.
Lead the development of new scientific approaches and knowledge within the global Material Sciences organization. This is an individual contributor role.
Basic Qualifications

Candidate s likely to have a PhD in Chemistry, Physics, Materials Science or Engineering, or a closely-related discipline; Or a Masterís degree in these disciplines with 5-10 years of relevant experience in industry or academia. This is an individual contributor role.
Strong coding skills in a scientific programming language (such as C/C++, Python, Perl) with demonstrated evidence of coding expertise and data analysis.
Competency in UNIX/Linux and HPC environments for submission and monitoring of jobs.

click here for full details to apply
>>> more