CMAC Publications



Al-Sharabi, M.;  Markl, D.;  Vivacqua, V.;  Bawuah, P.;  MacLean, N.;  Bentley, M.;  York, A. P. E.;  Marigo, M.;  Huang, K.; Zeitler, J. A., Terahertz pulsed imaging as a new method for investigating the liquid transport kinetics of α-alumina powder compacts. Chemical Engineering Research and Design 2021, 165, 386-397.  

Bawuah, P.;  Markl, D.;  Turner, A.;  Evans, M.;  Portieri, A.;  Farrell, D.;  Lucas, R.;  Anderson, A.;  Goodwin, D. J.; Zeitler, J. A., A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets. Journal of Pharmaceutical Sciences 2021, 110 (5), 2083-2092.

Benyahia, B.;  Anandan, P. D.; Rielly, C., Control of Batch and Continuous Crystallization Processes using Reinforcement Learning. In Computer Aided Chemical Engineering, Türkay, M.; Gani, R., Eds. Elsevier: 2021; Vol. 50, pp 1371-1376.

Briggs, N. E. B.;  McGinty, J.;  McCabe, C.;  Raval, V.;  Sefcik, J.; Florence, A. J., Heat Transfer and Residence Time Distribution in Plug Flow Continuous Oscillatory Baffled Crystallizers. ACS Omega 2021, 6 (28), 18352-18363.

Capdevila-Echeverria, J.;  Wang, J.;  Lakerveld, R.; ter Horst, J. H., Process modeling and optimization of continuous chiral resolution by integration of membrane and crystallization technologies. Journal of Membrane Science 2021, 632, 119359.

Febra, S. A.;  Bernet, T.;  Mack, C.;  McGinty, J.;  Onyemelukwe, I. I.;  Urwin, S. J.;  Sefcik, J.;  ter Horst, J. H.;  Adjiman, C. S.;  Jackson, G.; Galindo, A., Extending the SAFT-γ Mie approach to model benzoic acid, diphenylamine, and mefenamic acid: solubility prediction and experimental measurement. Fluid Phase Equilibria 2021, 113002.

Maclean, N.;  Walsh, E.;  Soundaranathan, M.;  Khadra, I.;  Mann, J.;  Williams, H.; Markl, D., Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations. International Journal of Pharmaceutics 2021, 599, 120221.

Markl, D.;  Maclean, N.;  Mann, J.;  Williams, H.;  Abbott, A.;  Mead, H.; Khadra, I., Tablet disintegration performance: Effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics. International Journal of Pharmaceutics 2021, 601, 120382.

Ottoboni, S.;  Wareham, B.;  Vassileiou, A.;  Robertson, M.;  Brown, C. J.;  Johnston, B.; Price, C. J., A Novel Integrated Workflow for Isolation Solvent Selection Using Prediction and Modeling. Organic Process Research & Development 2021

Pallipurath, A. R.;  Skelton, J. M.;  Britton, A.;  Willneff, E. A.; Schroeder, S. L. M., Bulk and Surface Conformations in Solid-State Lovastatin: Spectroscopic and Molecular Dynamics Studies. Crystals 2021, 11 (5), 509.

Saunders, L. K.;  Pallipurath, A. R.;  Gutmann, M. J.;  Nowell, H.;  Zhang, N.; Allan, D. R., A quantum crystallographic approach to short hydrogen bonds. CrystEngComm 2021, 23 (35), 6180-6190.

Shahid, M.;  Sanxaridou, G.;  Ottoboni, S.;  Lue, L.; Price, C., Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity. Organic Process Research & Development 2021, 25 (4), 969-981.

Stranzinger, S.;  Markl, D.;  Khinast, J. G.; Paudel, A., Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing. TrAC Trends in Analytical Chemistry 2021, 135, 116147.

Urwin, S. J.;  Yerdelen, S.;  Houson, I.; ter Horst, J. H., Impact of Impurities on Crystallization and Product Quality: A Case Study with Paracetamol. Crystals 2021, 11 (11), 1344.

Watson, O. L.;  Jonuzaj, S.;  McGinty, J.;  Sefcik, J.;  Galindo, A.;  Jackson, G.; Adjiman, C. S., Computer Aided Design of Solvent Blends for Hybrid Cooling and Antisolvent Crystallization of Active Pharmaceutical Ingredients. Organic Process Research & Development 2021, 25 (5), 1123-1142.

Yang, Y.;  Ahmed, B.;  Mitchell, C.;  Quon, J. L.;  Siddique, H.;  Houson, I.;  Florence, A. J.; Papageorgiou, C. D., Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient. Organic Process Research & Development 2021 , 25 (9), 2119-2132.


 Al-Ani, A. J.;  Herdes, C.;  Wilson, C. C.; Castro-Dominguez, B., Engineering a New Access Route to Metastable Polymorphs with Electrical Confinement. Crystal Growth & Design 2020, 20 (3), 1451-1457. 

Al-Madhagi, L. H.;  Callear, S. K.; Schroeder, S. L. M., Hydrophilic and hydrophobic interactions in concentrated aqueous imidazole solutions: a neutron diffraction and total X-ray scattering study. Physical Chemistry Chemical Physics 2020, 22 (9), 5105-5113.

Al-Sharabi, M.;  Markl, D.;  Mudley, T.;  Bawuah, P.;  Karttunen, A.-P.;  Ridgway, C.;  Gane, P.;  Ketolainen, J.;  Peiponen, K.-E.;  Rades, T.; Zeitler, J. A., Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration. International Journal of Pharmaceutics 2020, 584, 119380.

Almeida, J.;  Bezerra, M.;  Markl, D.;  Berghaus, A.;  Borman, P.; Schlindwein, W., Development and Validation of an in-line API Quantification Method Using AQbD Principles Based on UV-Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Process. Pharmaceutics 2020 , 12 (2), 150.

Bawuah, P.;  Markl, D.;  Farrell, D.;  Evans, M.;  Portieri, A.;  Anderson, A.;  Goodwin, D.;  Lucas, R.; Zeitler, J. A., Terahertz-Based Porosity Measurement of Pharmaceutical Tablets: a Tutorial. Journal of Infrared, Millimeter, and Terahertz Waves 2020, 41 (4), 450-469.

Doerr, F. J. S.;  Burns, L. J.;  Lee, B.;  Hinds, J.;  Davis-Harrison, R. L.;  Frank, S. A.; Florence, A. J., Peptide Isolation via Spray Drying: Particle Formation, Process Design and Implementation for the Production of Spray Dried Glucagon. Pharmaceutical Research 2020, 37 (12), 255.

Doerr, F. J. S.; Florence, A. J., A micro-XRT image analysis and machine learning methodology for the characterisation of multi-particulate capsule formulations. International Journal of Pharmaceutics: X 2020, 2, 100041.  

Ferreira, C.;  Cardona, J.;  Agimelen, O.;  Tachtatzis, C.;  Andonovic, I.;  Sefcik, J.; Chen, Y.-C., Quantification of particle size and concentration using in-line techniques and multivariate analysis. Powder Technology 2020, 376, 1-11.

Geyman, C., Settanni, E., Srai, J.S., Understanding risk in pharmaceutical supply chains. 2020.  

Haslam, A. J.;  González-Pérez, A.;  Di Lecce, S.;  Khalit, S. H.;  Perdomo, F. A.;  Kournopoulos, S.;  Kohns, M.;  Lindeboom, T.;  Wehbe, M.;  Febra, S.;  Jackson, G.;  Adjiman, C. S.; Galindo, A., Expanding the Applications of the SAFT-γ Mie Group-Contribution Equation of State: Prediction of Thermodynamic Properties and Phase Behavior of Mixtures. Journal of Chemical & Engineering Data 2020, 65 (12), 5862-5890.

Hatcher, L. E.;  Burgess, A. J.;  Payne, P.; Wilson, C. C., From structure to crystallisation and pharmaceutical manufacturing: the CSD in CMAC workflows. CrystEngComm 2020

Hatcher, L. E.;  Li, W.;  Payne, P.;  Benyahia, B.;  Rielly, C. D.; Wilson, C. C., Tuning Morphology in Active Pharmaceutical Ingredients: Controlling the Crystal Habit of Lovastatin through Solvent Choice and Non-Size-Matched Polymer Additives. Crystal Growth & Design 2020, 20 (9), 5854-5862.

Jonuzaj, S.;  Watson, O. L.;  Ottoboni, S.;  Price, C. J.;  Sefcik, J.;  Galindo, A.;  Jackson, G.; Adjiman, C. S., Computer-aided Solvent Mixture Design for the Crystallisation and Isolation of Mefenamic Acid. In Computer Aided Chemical Engineering, Pierucci, S.;  Manenti, F.;  Bozzano, G. L.; Manca, D., Eds. Elsevier: 2020; Vol. 48, pp 649-654.

Lakerveld, R.; Benyahia, B., CHAPTER 4 Process Control. In The Handbook of Continuous Crystallization, The Royal Society of Chemistry: 2020; pp 172-218.  

Levenstein, M. A.;  Wayment, L.;  Scott, C. D.;  Lunt, R.;  Flandrin, P.-B.;  Day, S. J.;  Tang, C. C.;  Wilson, C. C.;  Meldrum, F. C.;  Kapur, N.; Robertson, K., Dynamic Crystallization Pathways of Polymorphic Pharmaceuticals Revealed in Segmented Flow with Inline Powder X-ray Diffraction. Analytical Chemistry 2020, 92 (11), 7754-7761.

Majchrzak, A., Netland, N., Srai, J.S., Innovation in next generation production platforms, 2020

Markl, D.;  Warman, M.;  Dumarey, M.;  Bergman, E.-L.;  Folestad, S.;  Shi, Z.;  Manley, L. F.;  Goodwin, D. J.; Zeitler, J. A., Review of real-time release testing of pharmaceutical tablets: State-of-the art, challenges and future perspective. International Journal of Pharmaceutics 2020, 582, 119353.

McGinty, J.;  Chong, M. W. S.;  Manson, A.;  Brown, C. J.;  Nordon, A.; Sefcik, J., Effect of Process Conditions on Particle Size and Shape in Continuous Antisolvent Crystallisation of Lovastatin. Crystals 2020, 10 (10), 925.

McGinty, J.;  Yazdanpanah, N.;  Price, C.;  ter Horst, J. H.; Sefcik, J., CHAPTER 1 Nucleation and Crystal Growth in Continuous Crystallization. In The Handbook of Continuous Crystallization, The Royal Society of Chemistry: 2020; pp 1-50.

McKechnie, D.;  Anker, S.;  Zahid, S.;  Mulheran, P. A.;  Sefcik, J.; Johnston, K., Interfacial Concentration Effect Facilitates Heterogeneous Nucleation from Solution. The Journal of Physical Chemistry Letters 2020, 11 (6), 2263-2271.

Naftaly, M.;  Tikhomirov, I.;  Hou, P.; Markl, D., Measuring Open Porosity of Porous Materials Using THz-TDS and an Index-Matching Medium. Sensors 2020, 20 (11), 3120.

Onyemelukwe, I. I.;  Nagy, Z. K.; Rielly, C. D., Solid-liquid axial dispersion performance of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions using a non-invasive dual backlit imaging technique. Chemical Engineering Journal 2020, 382, 122862.   

Ottoboni, S.;  Coleman, S. J.;  Steven, C.;  Siddique, M.;  Fraissinet, M.;  Joannes, M.;  Laux, A.;  Barton, A.;  Firth, P.;  Price, C. J.; Mulheran, P. A., Understanding API Static Drying with Hot Gas Flow: Design and Test of a Drying Rig Prototype and Drying Modeling Development. Organic Process Research & Development 2020

Ottoboni, S.;  Shahid, M.;  Steven, C.;  Coleman, S.;  Meehan, E.;  Barton, A.;  Firth, P.;  Sutherland, R.; Price, C. J., Developing a Batch Isolation Procedure and Running It in an Automated Semicontinuous Unit: AWL CFD25 Case Study. Organic Process Research & Development 2020, 24 (4), 520-539.

Ottoboni, S.;  Simurda, M.;  Wilson, S.;  Irvine, A.;  Ramsay, F.; Price, C. J., Understanding effect of filtration and washing on dried product: Paracetamol case study. Powder Technology 2020

Pallipurath, A. R.;  Flandrin, P.-B.;  Wayment, L. E.;  Wilson, C. C.; Robertson, K., In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation. Molecular Systems Design & Engineering 2020, 5 (1), 294-303.

Prasad, E.;  Robertson, J.; Halbert, G. W., Improving Consistency for a Mefenamic Acid Immediate Release Formulation. Journal of Pharmaceutical Sciences 2020, 109 (11), 3462-3470.

Price, C. J.;  Barton, A.; Coleman, S. J., CHAPTER 13 Continuous Isolation of Active Pharmaceutical Ingredients. In The Handbook of Continuous Crystallization, The Royal Society of Chemistry: 2020; pp 469-507.

Ramakers, L. A. I.;  McGinty, J.;  Beckmann, W.;  Levilain, G.;  Lee, M.;  Wheatcroft, H.;  Houson, I.; Sefcik, J., Investigation of Metastable Zones and Induction Times in Glycine Crystallisation across Three Different Antisolvents. Crystal Growth & Design 2020

Raval, V.;  Siddique, H.;  Brown, C. J.; Florence, A. J., Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC). CrystEngComm 2020, 22 (13), 2288-2296.

Reed, B. P.;  Cant, D. J. H.;  Spencer, S. J.;  Carmona-Carmona, A. J.;  Bushell, A.;  Herrera-Gómez, A.;  Kurokawa, A.;  Thissen, A.;  Thomas, A. G.;  Britton, A. J.;  Bernasik, A.;  Fuchs, A.;  Baddorf, A. P.;  Bock, B.;  Theilacker, B.;  Cheng, B.;  Castner, D. G.;  Morgan, D. J.;  Valley, D.;  Willneff, E. A.;  Smith, E. F.;  Nolot, E.;  Xie, F.;  Zorn, G.;  Smith, G. C.;  Yasufuku, H.;  Fenton, J. L.;  Chen, J.;  Counsell, J. D. P.;  Radnik, J.;  Gaskell, K. J.;  Artyushkova, K.;  Yang, L.;  Zhang, L.;  Eguchi, M.;  Walker, M.;  Hajdyła, M.;  Marzec, M. M.;  Linford, M. R.;  Kubota, N.;  Cortazar-Martínez, O.;  Dietrich, P.;  Satoh, R.;  Schroeder, S. L. M.;  Avval, T. G.;  Nagatomi, T.;  Fernandez, V.;  Lake, W.;  Azuma, Y.;  Yoshikawa, Y.; Shard, A. G., Versailles Project on Advanced Materials and Standards interlaboratory study on intensity calibration for x-ray photoelectron spectroscopy instruments using low-density polyethylene. J Vac Sci Technol A 2020, 38 (6), 063208.

Settanni, E., Those who do not move, do not notice their (supply) chains-inconvenient lessons from disruptions related to COVID-19. AI Soc 2020, 1-7. 

Settanni, E.;  Heijungs, R.; Srai, J., Where have all the equations gone? The forgotten algebra of qualitative structural modelling. SSRN Electronic Journal 2020.

Soundaranathan, M.; Vivattanaseth, P.; Walsh, E.;  Pitt, K.;  Johnston, B.; Markl, D., Quantification of swelling characteristics of pharmaceutical particles. International Journal of Pharmaceutics 2020 , 590, 119903.

Srai J.S., Settanni. E., Aulakh P.K., Evaluating the Business Case for Continuous Manufacturing of Pharmaceuticals: A Supply Network Perspective. In: Nagy Z., El Hagrasy A., Litster J. (eds) Continuous Pharmaceutical Processing. AAPS Advances in the Pharmaceutical Sciences Series 2020, 42.

Srirambhatla, V. K.;  Guo, R.;  Dawson, D. M.;  Price, S. L.; Florence, A. J., Reversible, Two-Step Single-Crystal to Single-Crystal Phase Transitions between Desloratadine Forms I, II, and III. Crystal Growth & Design 2020, 20 (3), 1800-1810.

Stevens, J. S.;  Coultas, S.;  Jaye, C.;  Fischer, D. A.; Schroeder, S. L. M., Core level spectroscopies locate hydrogen in the proton transfer pathway – identifying quasi-symmetrical hydrogen bonds in the solid state. Physical Chemistry Chemical Physics 2020, 22 (9), 4916-4923.

Urwin, S. J.;  Levilain, G.;  Marziano, I.;  Merritt, J. M.;  Houson, I.; Ter Horst, J. H., A Structured Approach To Cope with Impurities during Industrial Crystallization Development. Organic Process Research & Development 2020, 24 (8), 1443-1456.

Warzecha, M.;  Verma, L.;  Johnston, B. F.;  Palmer, J. C.;  Florence, A. J.; Vekilov, P. G., Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers. Nature Chemistry 2020 , 12 (10), 914-920


Ahmed, B.;  Brown, C. J.;  McGlone, T.;  Bowering, D. L.;  Sefcik, J.; Florence, A. J., Engineering of acetaminophen particle attributes using a wet milling crystallisation platform. 2019, 554, 201-211.

Arjmandi-Tash, O.;  Tew, J. D.;  Pitt, K.;  Smith, R.; Litster, J. D., A new mathematical model for nucleation of spherical agglomerates by the immersion mechanism. Chemical Engineering Science: X 2019, 4, 100048

Bordos, E.; Islam, M. T.; Florence, A. J.; Halbert, G. W.; Robertson. Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion J. Molecular Pharmaceutics 2019, 16, 4361.

Briuglia, M. L.; Sefcik, J.; ter Horst, J. H., Measuring Secondary Nucleation through Single Crystal Seeding. Crystal Growth & Design 2019, 19, 421-429.

Chang, S. Y.;  Kathyola, T. A.;  Willneff, E. A.;  Willis, C. J.;  Wilson, P.;  Dowding, P. J.;  Cibin, G.;  Kroner, A. B.;  Shotton, E. J.; Schroeder, S. L. M., A versatile liquid-jet/sessile droplet system for operando studies of reactions in liquid dispersions and solutions by X-ray absorption spectroscopy. Reaction Chemistry & Engineering 2019, 4 (4), 679-687

Connor, L. E.; Vassileiou, A. D.; Halbert, G. W.; Johnston, B. F.; Oswald, I. D. H., Structural investigation and compression of a co-crystal of indomethacin and saccharin. CrystEngComm 2019 .   

Dunn, A. S.; Svoboda, V.; Sefcik, J.; ter Horst. Resolution control in a continuous preferential crystallization process. Organic Process Research & Development2019 23 (9), 2031-2041.

Edinger, M.; Iftimi, L.-D.; Markl, D.; Al-Sharabi, M.; Bar-Shalom, D.; Rantanen, J.; Genina, N., Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy. AAPS PharmSciTech 2019, 20, 207.

Febra, S. A.;  Aasen, A.;  Adjiman, C. S.;  Jackson, G.; Galindo, A., Intramolecular bonding in a statistical associating fluid theory of ring aggregates. Molecular Physics 2019, 1-29. 

Fysikopoulos, D.;  Benyahia, B.;  Borsos, A.;  Nagy, Z. K.; Rielly, C. D., A framework for model reliability and estimability analysis of crystallization processes with multi-impurity multi-dimensional population balance models. Computers & Chemical Engineering 2019, 122, 275-292.

Jiang, M.; Ni, X.-W., Reactive Crystallization of Paracetamol in a Continuous Oscillatory Baffled Reactor. Organic Process Research & Development 2019, 23, 882-890.

Jiang, M.; Ni, X.-W., Effects of solvents and impurity on crystallization kinetics and crystal properties in a reactive crystallization of paracetamol. Journal of Crystal Growth 2019, 523, 125150.

Jimeno, G.; Lee, Y. C.; Ni, X.-W., Smoothed particle hydrodynamics – A new approach for modeling flow in oscillatory baffled reactors. Computers & Chemical Engineering 2019, 124, 14-27.

Jolliffe, H. G.;  Papathanasiou, F.;  Prasad, E.;  Halbert, G.;  Robertson, J.;  Brown, C. J.; Florence, A. J., Improving the prediction of multi-component tablet properties from pure component parameters. In Computer Aided Chemical Engineering, Kiss, A. A.;  Zondervan, E.;  Lakerveld, R.; Özkan, L., Eds. Elsevier: 2019; Vol. 46, pp 883-888.

Konar, S.;  Michalchuk, A. A. L.;  Sen, N.;  Bull, C. L.;  Morrison, C. A.; Pulham, C. R., High-Pressure Study of Two Polymorphs of 2,4,6-Trinitrotoluene Using Neutron Powder Diffraction and Density Functional Theory Methods. The Journal of Physical Chemistry C 2019, 123 (43), 26095-26105.    

Marathe, S.;  Storm, M.;  Kuppilli, V. S. C.;  Harrison, R.;  Das, G.;  Schroeder, S. L. M.;  Cipiccia, S.;  Döring, F.;  David, C.; Rau, C., Development of synchrotron pink beam x-ray grating interferometer at the Diamond Light source I13-2 beamline. SPIE: 2019; Vol. 11113.  

Mendez Torrecillas, C.; Gorringe, L. J.; Rajoub, N.; Robertson, J.; Elkes, R. G.; Lamprou, D. A.; Halbert, G. W., The impact of channel fill level on internal forces during continuous twin screw wet granulation. International journal of pharmaceutics 2019, 558, 91-100.

Michalchuk, A. A. L.;  Trestman, M.;  Rudić, S.;  Portius, P.;  Fincham, P. T.;  Pulham, C. R.; Morrison, C. A., Predicting the reactivity of energetic materials: an ab initio multi-phonon approach. Journal of Materials Chemistry A 2019, 7 (33), 19539-19553.

Onyemelukwe, I., Nagy, Z.K., Rielly, C.D. 2019. Solid-liquid axiald dispersion performance of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions using a non-invasive dual backlit imaging technique, Chem. Eng. J.  2019

Onyemelukwe, I. I.; Parsons, A. R.; Wheatcroft, H. P.; Robertson, A.; Nagy, Z. K.; Rielly, C. D., The Role of Residence Time Distribution in the Continuous Steady-State Mixed Suspension Mixed Product Removal Crystallization of Glycine. Crystal Growth & Design 2019, 19, 66-80.

Prasad, E.; Islam, M. T.; Goodwin, D. J.; Megarry, A. J.; Halbert, G. W.; Florence, A. J.; Robertson, J., Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisol™ 15LV filaments for fused filament fabrication (FFF) 3D printing. Additive Manufacturing 2019, 29, 100776.

Rau, C.;  Storm, M.;  Marathe, S.;  Bodey, A.;  Zdora, M.;  Cipiccia, S.;  Batey, D.;  Shi, X.;  Schroeder, S. M. L.;  Das, G.;  Loveridge, M.;  Ziesche, R.; Connolly, B., Fast Multi-scale imaging using the Beamline I13L at the Diamond Light Source. SPIE: 2019; Vol. 11113. 

Srai, J.S., The role of collaborative e-sourcing in supply chain digitalization scenarios: A gamification-enabled structural model. 2019

Srai, J. S. Badman, C., Collaboration as the Best Medicine. Chimica Oggi-Chemistry Today 2019, 37 (1), 56-59.

Srai, J. S. S., E.; Tsolakis, N.; Aulakh, P. K. , Supply Chain Digital Twins: Opportunities and Challenges Beyond the Hype 23rd Cambridge International Manufacturing Symposium University of Cambridge, 26 – 27 September 2019.  

Stranzinger, S.; Faulhammer, E.; Li, J.; Dong, R.; Khinast, J. G.; Zeitler, J. A.; Markl, D., Measuring bulk density variations in a moving powder bed via terahertz in-line sensing. Powder Technology 2019, 344, 152-160.   

Tahir, F.;  Islam, M. T.;  Mack, J.;  Robertson, J.; Lovett, D., Process monitoring and fault detection on a hot-melt extrusion process using in-line Raman spectroscopy and a hybrid soft sensor. Computers & Chemical Engineering 2019, 125, 400-414.

Turner, T. D.;  Hatcher, L. E.;  Wilson, C. C.; Roberts, K. J., Habit Modification of the Active Pharmaceutical Ingredient Lovastatin Through a Predictive Solvent Selection Approach. J Pharm Sci 2019, 108 (5), 1779-1787.

Vesga, M. J.; McKechnie, D.; Mulheran, P. A.; Johnston, K.; Sefcik, J., Conundrum of γ glycine nucleation revisited: to stir or not to stir? CrystEngComm 2019, 21, 2234-2243.

Ward, M. R.; Oswald, I. D. H., Antisolvent addition at extreme conditions. CrystEngComm 2019  

Watson, O. L.;  Galindo, A.;  Jackson, G.; Adjiman, C. S., Computer-aided Design of Solvent Blends for the Cooling and Anti-solvent Crystallisation of Ibuprofen. In Computer Aided Chemical Engineering, Kiss, A. A.;  Zondervan, E.;  Lakerveld, R.; Özkan, L., Eds. Elsevier: 2019; Vol. 46, pp 949-954

Wongpinyochit, T.;  Vassileiou, A. D.;  Gupta, S.;  Mushrif, S. H.;  Johnston, B. F.; Seib, F. P., Unraveling the Impact of High-Order Silk Structures on Molecular Drug Binding and Release Behaviors. The Journal of Physical Chemistry Letters 2019, 10 (15), 4278-4284.

Xiouras, C.;  Belletti, G.;  Venkatramanan, R.;  Nordon, A.;  Meekes, H.;  Vlieg, E.;  Stefanidis, G. D.; Ter Horst, J. H., Toward Continuous Deracemization via Racemic Crystal Transformation Monitored by in Situ Raman Spectroscopy. Crystal Growth & Design 2019, 19 (10), 5858-5868

Zimbitas, G.; Jawor-Baczynska, A.; Vesga, M. J.; Javid, N.; Moore, B. D.; Parkinson, J.; Sefcik, J. Investigation of molecular and mesoscale clusters in undersaturated glycine aqueous solutions. Colloids and Surfaces A2019 579, 123633.

Agimelen, O. S.; Svoboda, V.; Ahmed, B.; Cardona, J.; Dziewierz, J.; Brown, C. J.; McGlone, T.; Cleary, A.; Tachtatzis, C.; Michie, C.; Florence, A. J.; Andonovic, I.; Mulholland, A. J.; Sefcik, J., Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries. Advanced Powder Technology 2018, 29, 2987-2995.

Al-Madhagi, L. H.;  Chang, S.-Y.;  Balasubramanian, M.;  Kroner, A. B.;  Shotton, E. J.;  Willneff, E. A.;  Mishra, B.; Schroeder, S. L. M., X-ray Raman scattering: a new in situ probe of molecular structure during nucleation and crystallization from liquid solutions. CrystEngComm 2018, 20 (43), 6871-6884.

Bhardwaj, R. M.; Reutzel-Edens, S. M.; Johnston, B. F.; Florence, A. J., A random forest model for predicting crystal packing of olanzapine solvates. CrystEngComm 2018, 20, 3947-3950.

Bouvart, N.; Palix, R.-M.; Arkhipov, S. G.; Tumanov, I. A.; Michalchuk, A. A. L.; Boldyreva, E. V., Polymorphism of chlorpropamide on liquid-assisted mechanical treatment: choice of liquid and type of mechanical treatment matter. CrystEngComm 2018. DOI: 10.1039/C7ME00096K

Brown, C. J.; McGlone, T.; Yerdelen, S.; Srirambhatla, V.; Mabbott, F.; Gurung, R.; L. Briuglia, M.; Ahmed, B.; Polyzois, H.; McGinty, J.; Perciballi, F.; Fysikopoulos, D.; MacFhionnghaile, P.; Siddique, H.; Raval, V.; Harrington, T. S.; Vassileiou, A. D.; Robertson, M.; Prasad, E.; Johnston, A.; Johnston, B.; Nordon, A.; Srai, J. S.; Halbert, G.; ter Horst, J. H.; Price, C. J.; Rielly, C. D.; Sefcik, J.; Florence, A. J., Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations. Molecular Systems Design & Engineering 2018.  DOI: 10.1039/C7ME00096K

Burcham, C. L.; Florence, A. J.; Johnson, M. D., Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing. Annual Review of Chemical and Biomolecular Engineering 2018, 9, 253-281.

Cardona, J.; Ferreira, C.; McGinty, J.; Hamilton, A.; Agimelen, O. S.; Cleary, A.; Atkinson, R.; Michie, C.; Marshall, S.; Chen, Y.-C.; Sefcik, J.; Andonovic, I.; Tachtatzis, C., Image analysis framework with focus evaluation for in situ characterisation of particle size and shape attributes. Chemical Engineering Science 2018, 191, 208-231.

Case, D. H.; Srirambhatla, V. K.; Guo, R.; Watson, R. E.; Price, L. S.; Polyzois, H.; Cockcroft, J. K.; Florence, A. J.; Tocher, D. A.; Price, S. L., Successful Computationally Directed Templating of Metastable Pharmaceutical Polymorphs. Crystal Growth & Design 2018, 18, 5322-5331. DOI: 10.1021/acs.cgd.8b00765

Doerr, F. J. S.; Oswald, I. D. H.; Florence, A. J., Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography. Advanced Powder Technology 2018. DOI: 10.1016/j.apt.2018.09.027

Forbes, C.; Nguyen, T.T.H; O'Leary, R.L.; Price, C.J., Elucidating the mechanism of paracetamol sonocrystallization for product purity enhancement.   Proceedings of Meetings on Acoustics2018 32, ICU2017 - 287.

Harrington, T. S.; Burge, T. A., Connecting digital pharma and e-healthcare value networks through product-service design: a conceptual model. International Journal of Electronic Healthcare 2018, 10 (1-2), 96-129.

Harrington, T. S.;  Srai, J. S.; Najim, I., Emerging product-process archetypes in oncology: informing the sustainable provision of next-generation medicines. International Journal of Healthcare Technology and Management 2018, 17 (2-3), 97-127.

Hatcher, L.; CCDC 1829765: Experimental Crystal Structure Determination, 2018, DOI: 10.5517/ccdc.csd.cc1zf0p3

Jiang, M.; Ni, X.-W., Effects of water and temperature on reaction mechanism and crystal properties in a reactive crystallization of paracetamol. Chemical Engineering and Processing - Process Intensification 2018, 131, 20-26.

Jimeno, G.; Lee, Y. C.; Ni, X.-W., On the evaluation of power density models for oscillatory baffled reactors using CFD. Chemical Engineering and Processing - Process Intensification 2018, 134, 153-162. DOI: 10.1016/j.cep.2018.11.002

Kathyola, T., In situ monitoring of the reactive crystallization of calcium carbonate in multiphase systems. In 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, Abstracts of Papers Of The American Chemical Society: 2018; Vol. 255.

Kongsamai, P.;  Flood, C.;  ter Horst, J. H.; Flood, A. E., Particle Size Distributions and Performance of Preferential Crystallization of L-Asparagine·H2O with Tailor-Made Additives. Chemical Engineering & Technology 2018, 41 (6), 1173-1179.

Laskar, P.;  Somani, S.;  Altwaijry, N.;  Mullin, M.;  Bowering, D.;  Warzecha, M.;  Keating, P.;  Tate, R. J.;  Leung, H. Y.; Dufès, C., Redox-sensitive, cholesterol-bearing PEGylated poly(propylene imine)-based dendrimersomes for drug and gene delivery to cancer cells. Nanoscale 2018, 10 (48), 22830-22847.  

Lin, H.; Zhang, Z.; Markl, D.; Zeitler, J. A.; Shen, Y., A Review of the Applications of OCT for Analysing Pharmaceutical Film Coatings. Applied Sciences 2018, 8, 2700. DOI: 10.3390/app8122700

McLaughlin, A,M.; Robertson, J.; Ni,  X., Material characterisation and parameter effects on bulk solid dissolution rate of paracetamol in a stirred tank vessel using an in situ UV-ATR probe. International Journal of Engineering Research & Science20184(1):10-20.

Michalchuk, A. A. L.; Hope, K. S.; Kennedy, S. R.; Blanco, M.; Boldyreva, E.; Pulham, C. R., Ball-Free Mechanochemistry: In Situ Real-Time Monitoring of Pharmaceutical Co-Crystal Synthesis by Resonant Acoustic Mixing. Chemical Communications 2018.

Michalchuk, A. A. L.; Fincham, P. T.; Portius, P.; Pulham, C. R.; Morrison, C. A., A Pathway to the Athermal Impact Initiation of Energetic Azides. The Journal of Physical Chemistry C 2018, 122, 19395-19408.

Michalchuk, A. A. L.;  Rudić, S.;  Pulham, C. R.; Morrison, C. A., Vibrationally induced metallisation of the energetic azide α-NaN3. Physical Chemistry Chemical Physics 2018, 20 (46), 29061-29069.

Michalchuk, A. A. L.;  Tumanov, I. A.; Boldyreva, E. V., The effect of ball mass on the mechanochemical transformation of a single-component organic system: anhydrous caffeine. Journal of Materials Science 2018, 53 (19), 13380-13389.

Neugebauer, P.; Cardona, J.; Besenhard, M. O.; Peter, A.; Gruber-Woelfler, H.; Tachtatzis, C.; Cleary, A.; Andonovic, I.; Sefcik, J.; Khinast, J. G., Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer. Crystal Growth & Design 2018. DOI: 10.1021/acs.cgd.8b00371

Onyemelukwe, I. I.; Benyahia, B.; Reis, N. M.; Nagy, Z. K.; Rielly, C. D., The heat transfer characteristics of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions. International Journal of Heat and Mass Transfer 2018, 123, 1109-1119. DOI: 10.1016/j.ijheatmasstransfer.2018.03.015

Onyemelukwe, I.I.; Parsons, A.R.; Wheatcroft, H.P.; Robertson, A.; Nagy, Z.K.; Rielly, C.D. The role of residence time distribution in the continuous steady-state MSMPR crystallization of glycine. Crystal Growth & Design 2018, DOI: 10.1021/acs.cgd.8b00853

Ottoboni, S.; Chrubasik, M.; Mir Bruce, L.; Nguyen, T. T. H.; Robertson, M.; Johnston, B.; Oswald, I. D. H.; Florence, A.; Price, C., Impact of Paracetamol Impurities on Face Properties: Investigating the Surface of Single Crystals Using TOF-SIMS. Crystal Growth & Design 2018, 18, 2750-2758. DOI: 10.1021/acs.cgd.7b01411

Ottoboni, S.; Price, C. J.; Steven, C.; Meehan, E.; Barton, A.; Firth, P.; Mitchell, A.; Tahir, F., Development of a Novel Continuous Filtration Unit for Pharmaceutical Process Development and Manufacturing. Journal of pharmaceutical sciences 2018. DOI: 10.1016/j.xphs.2018.07.005

Parekh, R.;  Benyahia, B.; Rielly, C. D., A Global State Feedback Linearization and Decoupling MPC of a MIMO Continuous MSMPR Cooling Crystallization Process. In Computer Aided Chemical Engineering, Friedl, A.;  Klemeš, J. J.;  Radl, S.;  Varbanov, P. S.; Wallek, T., Eds. Elsevier: 2018; Vol. 43, pp 1607-1612.

Phillips, M. A.; Srai, J. S., Exploring Emerging Ecosystem Boundaries: Defining ‘The Game’. International Journal of Innovation Management 2018, 22 (08), 1840012.

Pitt, K.; Peña, R.; Tew, J. D.; Pal, K.; Smith, R.; Nagy, Z. K.; Litster, J. D., Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling. Powder Technology 2017

Scott, C. D.; Labes, R.; Depardieu, M.; Battilocchio, C.; Davidson, M. G.; Ley, S. V.; Wilson, C. C.; Robertson, K., Integrated plug flow synthesis and crystallisation of pyrazinamide. Reaction Chemistry & Engineering 2018, 3, 631-634. DOI: 10.1039/C8RE00087E

Settanni, E., Srai, J., & Kothapalli, V. M. , Combining field data analysis and simulation to evaluate an alternative Just-In-Time clinical trial supply strategy. 22nd Cambridge International Manufacturing Symposium. 2018.

Settanni, E.S.; Srai, J., Digitalisation of the UK Manufacturing Economy: Structural Dependencies and Implications for Intervention Strategies.  SSRN Electronic Journal,  2018.

Settanni, E. S., Srai J., Towards a new approach to modelling pharmaceutical supply chains in a changing technological landscape. Pharma Horizon 2018, 2 (1), 26-28.

Settanni, E., Srai, J., & Kothapalli, V. M.  Combining field data analysis and simulation to evaluate an alternative Just-In-Time clinical trial supply strategy.  22nd Cambridge International Manufacturing Symposium.

Steendam, R. R. E.; ter Horst, J. H., Scaling Up Temperature Cycling-Induced Deracemization by Suppressing Nonstereoselective Processes. Crystal Growth & Design 2018, 18, 3008-3015.

Tsolakis, N.; Srai, J. S., Mapping supply dynamics in renewable feedstock enabled industries: A systems theory perspective on "green' pharmaceuticals. Operations Management Research 2018, 11 (3-4), 83-104.

Turner, T. D.; Hatcher, L. E.; Wilson, C. C.; Roberts, K. J., Habit Modification of the API Lovastatin through a Predictive Solvent Selection Approach. Journal of pharmaceutical sciences 2018.

Turner, T. D.; Lai, X.; Roberts, K. J., The thermal expansion coefficients of the alpha and beta polymorphic forms of p-aminobenzoic acid in relation to their bulk crystal chemistry. CrystEngComm 2018, 20, 4099-4102. DOI: 10.1039/C8CE00539G

Wongpinyochit, T.; Johnston, B. F.; Seib, F. P., Degradation Behavior of Silk Nanoparticles—Enzyme Responsiveness. ACS Biomaterials Science & Engineering 2018, 4, 942-951. DOI: 10.1021/acsbiomaterials.7b01021


Agimelen, Okpeafoh S., Mulholland, Anthony J., & Sefcik, Jan. (2017). Modelling of artefacts in estimations of particle size of needle-like particles from laser diffraction measurements. Chemical Engineering Science, 158, 445-452. doi:

Agnew, Lauren R., McGlone, Thomas, Wheatcroft, Helen P., Robertson, Amy, Parsons, Anna R., & Wilson, Chick C. (2017). Continuous Crystallization of Paracetamol (Acetaminophen) Form II: Selective Access to a Metastable Solid Form. Crystal Growth & Design, 17(5), 2418-2427. doi: 10.1021/acs.cgd.6b01831

Connor, L. E., Morrison, C. A., Oswald, I. D. H., Pulham, C. R., & Warren, M. R. (2017). Carbon dioxide binary crystals via the thermal decomposition of RDX at high pressure. Chemical Science. doi: 10.1039/C7SC01379E

Ejim, Louisa N., Yerdelen, Stephanie, McGlone, Thomas, Onyemelukwe, Iyke, Johnston, Blair, Florence, Alastair J., & Reis, Nuno M. (2017). A factorial approach to understanding the effect of inner geometry of baffled meso-scale tubes on solids suspension and axial dispersion in continuous, oscillatory liquid–solid plug flows. Chemical Engineering Journal, 308, 669-682. doi:

Fysikopoulos, D.;  Borsos, A.;  Li, W.;  Onyemelukwe, I.;  Benyahia, B.;  Nagy, Z. K.; Rielly, C. D., Local vs Global Estimability Analysis of Population Balance Models for Crystallization Processes. In Computer Aided Chemical Engineering, Espuña, A.;  Graells, M.; Puigjaner, L., Eds. Elsevier: 2017; Vol. 40, pp 55-60.

Hall Barrientos, Ivan J., Paladino, Eleonora, Brozio, Sarah, Passarelli, Melissa K., Moug, Susan, Black, Richard A., . . . Lamprou, Dimitrios A. (2017). Fabrication and characterisation of drug-loaded electrospun polymeric nanofibers for controlled release in hernia repair. International Journal of Pharmaceutics, 517(1), 329-337. doi:

Hall Barrientos, Ivan J., Paladino, Eleonora, Szabó, Peter, Brozio, Sarah, Hall, Peter J., Oseghale, Charles I., . . . Lamprou, Dimitrios A. (2017). Electrospun collagen-based nanofibres: A sustainable material for improved antibiotic utilisation in tissue engineering applications. International Journal of Pharmaceutics, 531(1), 67-79. doi:

Halliwell, Rebecca A., Bhardwaj, Rajni M., Brown, Cameron J., Briggs, Naomi E. B., Dunn, Jaclyn, Robertson, John, . . . Florence, Alastair J. (2017). Spray Drying as a Reliable Route to Produce Metastable Carbamazepine Form IV. Journal of Pharmaceutical Sciences, 106(7), 1874-1880. doi:

Harrington, T. S.;  Phillips, M. A.; Srai, J. S., Reconfiguring global pharmaceutical value networks through targeted technology interventions. International Journal of Production Research 2017, 55 (5), 1471-1487.

Johnston, Andrea, Bhardwaj-Miglani, Rajni, Gurung, Rajesh, Vassileiou, Antony D., Florence, Alastair J., & Johnston, Blair F. (2017). Combined Chemoinformatics Approach to Solvent Library Design Using clusterSim and Multidimensional Scaling. Journal of Chemical Information and Modeling, 57(8), 1807-1815. doi: 10.1021/acs.jcim.7b00038

Kimuli, E. N.;  Onyemelukwe, I. I.;  Benyahia, B.; Rielly, C. D., Characterisation of axial dispersion in a Meso-scale Oscillatory Baffled Crystalliser using a Numerical Approach. In Computer Aided Chemical Engineering, Espuña, A.;  Graells, M.; Puigjaner, L., Eds. Elsevier: 2017; Vol. 40, pp 223-228.

Kongsamai, Peetikamol, Maneedaeng, Atthaphon, Flood, Chalongsri, ter Horst, Joop H., & Flood, Adrian E. (2017). Effect of additives on the preferential crystallization of L-asparagine monohydrate. The European Physical Journal Special Topics, 226(5), 823-835. doi: 10.1140/epjst/e2016-60257-3

Kumar, M.;  Harrington, T. S.;  Srai, J. S.; Minakata, Y., Industrial system dynamics for environmental sustainability: a case study on the UK medical technology sector. International Journal of Manufacturing Technology and Management 2017, 31 (1/2/3), 100-132.

Lau, King Hang Aaron, Castelletto, Valeria, Kendall, Thomas, Sefcik, Jan, Hamley, Ian W., Reza, Mehedi, & Ruokolainen, Janne. (2017). Self-assembly of ultra-small micelles from amphiphilic lipopeptoids. Chemical Communications, 53(13), 2178-2181. doi: 10.1039/C6CC09888F

Liu, Yao, Ward, Martin R., & Alexander, Andrew J. (2017). Polarization independence of laser-induced nucleation in supersaturated aqueous urea solutions. Physical Chemistry Chemical Physics, 19(5), 3464-3467. doi: 10.1039/C6CP07997K

MacFhionnghaile, Pól, Svoboda, Vaclav, McGinty, John, Nordon, Alison, & Sefcik, Jan. (2017). Crystallization Diagram for Antisolvent Crystallization of Lactose: Using Design of Experiments To Investigate Continuous Mixing-Induced Supersaturation. Crystal Growth & Design, 17(5), 2611-2621. doi: 10.1021/acs.cgd.7b00136

Maitz, Manfred F., Sperling, Claudia, Wongpinyochit, Thidarat, Herklotz, Manuela, Werner, Carsten, & Seib, F. Philipp. (2017). Biocompatibility assessment of silk nanoparticles: hemocompatibility and internalization by human blood cells. Nanomedicine: Nanotechnology, Biology and Medicine. doi:

Marshall, Ross J., Kalinovskyy, Yaroslav, Griffin, Sarah L., Wilson, Claire, Blight, Barry A., & Forgan, Ross S. (2017). Functional Versatility of a Series of Zr Metal–Organic Frameworks Probed by Solid-State Photoluminescence Spectroscopy. Journal of the American Chemical Society, 139(17), 6253-6260. doi: 10.1021/jacs.7b02184

Mendez Torrecillas, Carlota, Halbert, Gavin W., & Lamprou, Dimitrios A. (2017). A novel methodology to study polymodal particle size distributions produced during continuous wet granulation. International Journal of Pharmaceutics, 519(1–2), 230-239. doi:

Michalchuk, Adam A. L., Tumanov, Ivan A., Konar, Sumit, Kimber, Simon A. J., Pulham, Colin R., & Boldyreva, Elena V. Challenges of Mechanochemistry: Is In Situ Real-Time Quantitative Phase Analysis Always Reliable? A Case Study of Organic Salt Formation. Advanced Science, 1700132-n/a. doi: 10.1002/advs.201700132

Nasr, Moheb M., Krumme, Markus, Matsuda, Yoshihiro, Trout, Bernhardt L., Badman, Clive, Mascia, Salvatore, . . . Lee, Sau L. (2017). Regulatory Perspectives on Continuous Pharmaceutical Manufacturing: Moving From Theory to Practice: September 26-27, 2016, International Symposium on the Continuous Manufacturing of Pharmaceuticals. Journal of Pharmaceutical Sciences. doi:

Nguyen, T.;  Khan, A.;  Bruce, L.;  Forbes, C.;  O’Leary, R.; Price, C., The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities. Crystals 2017, 7 (10), 294.

Osorio, Juan G., Sayin, Ridade, Kalbag, Arjun V., Litster, James D., Martinez-Marcos, Laura, Lamprou, Dimitrios A., & Halbert, Gavin W. (2017). Scaling of continuous twin screw wet granulation. AIChE Journal, 63(3), 921-932. doi: 10.1002/aic.15459

Phillips, M. A. H., T. S.; Srai, J. S.. Convergent Innovation in Emerging Healthcare Technology Ecosystems: Addressing Complexity and Integration. Technology Innovation Management Review 2017, 7 (9), 44-46.

Price, C. J., Application of Ultrasound in Crystallization (Sonocrystallization). In Engineering Crystallography: From Molecule to Crystal to Functional Form , Roberts, K. J.;  Docherty, R.; Tamura, R., Eds. Springer Netherlands: Dordrecht, 2017; pp 301-313.       

Price, C. J., Continuous Pharmaceutical Crystallization from Solution. In Engineering Crystallography: From Molecule to Crystal to Functional Form, Roberts, K. J.;  Docherty, R.; Tamura, R., Eds. Springer Netherlands: Dordrecht, 2017; pp 315-329.

Raza, S. A.;  Schacht, U.;  Svoboda, V.;  Edwards, D. P.;  Florence, A. J.;  Pulham, C. R.;  Sefcik, J.; Oswald, I. D. H., Rapid continuous antisolvent crystallization of multi-component systems. Crystal Growth & Design 2017, 18, (1), 210-218.   

S. de Moraes, Lygia, Edwards, Darren, Florence, Alastair J., Johnston, Andrea, Johnston, Blair F., Morrison, Catriona A., & Kennedy, Alan R. (2017). Aqueous Solubility of Organic Salts. Investigating Trends in a Systematic Series of 51 Crystalline Salt Forms of Methylephedrine. Crystal Growth & Design. doi: 10.1021/acs.cgd.7b00255

Saborano, Raquel, Wongpinyochit, Thidarat, Totten, John D., Johnston, Blair F., Seib, F. Philipp, & Duarte, Iola F. (2017). Metabolic Reprogramming of Macrophages Exposed to Silk, Poly(lactic-co-glycolic acid), and Silica Nanoparticles. Advanced Healthcare Materials, 1601240-n/a. doi: 10.1002/adhm.201601240

Settanni, E., Srai, J.S., Yatskovskaya, E. and Harrington, T.S. (2017). Exploring Generalisations for Sustainability Assessment in Medicine Manufacturing Networks: proceedings of the 24th International EurOMA Conference.

Settanni, Ettore, Harrington, Tomás Seosamh, & Srai, Jagjit Singh. (2017). Pharmaceutical supply chain models: A synthesis from a systems view of operations research. Operations Research Perspectives, 4(Supplement C), 74-95.

Simone, Elena, Klapwijk, Anneke R., Wilson, Chick C., & Nagy, Zoltan K. (2017). Investigation of the Evolution of Crystal Size and Shape during Temperature Cycling and in the Presence of a Polymeric Additive Using Combined Process Analytical Technologies. Crystal Growth & Design, 17(4), 1695-1706.   

Steendam, René R. E., & ter Horst, Joop H. (2017). Continuous Total Spontaneous Resolution. Crystal Growth & Design, 17(8), 4428-4436.

Srai, J. S., Mapping industrial systems - a supply network perspective on enabling technologies, processes and actors. International Journal of Manufacturing Technology and Management 2017, 31 (1-3), 82-99.

Srai, J. S., Mapping industrial systems - a supply network perspective on enabling technologies, processes and actors. International Journal of Manufacturing Technology and Management 2017, 31 (1-3), 82-99.

Srai, J. S., Future supply chains: Unlocking your digital potential. In Journal of Manufacturing Leadership, 2017; pp 49-55.

Srai, J. S., Next generation supply chains: Making the right decisions about digitalisation; 2017.

Srai, J. S., Take your medicine - How new research into pharmaceutical supply chains will help you take care of yourself. Research Horizons 2017

Trokanas, N.; Srai, J. S., Towards an Ontological Backbone for Pharmaceutical Digital Supply Chains. In Computer Aided Chemical Engineering, Espuña, A.;  Graells, M.; Puigjaner, L., Eds. Elsevier: 2017; Vol. 40, pp 2329-2334.

Warzecha, M.;  Guo, R.;  M. Bhardwaj, R.;  Reutzel-Edens, S. M.;  Price, S. L.;  Lamprou, D. A.; Florence, A. J., Direct Observation of Templated Two-Step Nucleation Mechanism during Olanzapine Hydrate Formation. Crystal Growth & Design 2017, 17 (12), 6382-6393.

Warzecha, M.;  Safari, M. S.;  Florence, A. J.; Vekilov, P. G., Mesoscopic Solute-Rich Clusters in Olanzapine Solutions. Crystal Growth & Design 2017, 17 (12), 6668-6676.


Adelakun, J. A. N., Xiong-Wei, On the Kinetics of Palm Oil Crystallisation. International Journal of Engineering Research & Science 2016, 2 (10), 1.

Agimelen, O. S.;  Jawor-Baczynska, A.;  McGinty, J.;  Dziewierz, J.;  Tachtatzis, C.;  Cleary, A.;  Haley, I.;  Michie, C.;  Andonovic, I.;  Sefcik, J.; Mulholland, A. J., Integration of in situ imaging and chord length distribution measurements for estimation of particle size and shape. Chemical Engineering Science 2016, 144, 87-100.

Agnew, L. R.;  Cruickshank, D. L.;  McGlone, T.; Wilson, C. C., Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment. Chemical Communications 2016, 52, (46), 7368-71.

Bhardwaj, R. M.;  Yang, H.; Florence, A. J., Crystal structure of the co-crystal butylparaben–isonicotinamide (1/1). Acta Crystallographica Section E: Crystallographic Communications 2016, 72 (1), 53-55.

Brandel, C.;  Cartigny, Y.;  Coquerel, G.;  ter Horst, J. H.; Petit, S., Prenucleation Self-Assembly and Chiral Discrimination Mechanisms during Solution Crystallisation of Racemic Diprophylline. Chemistry – A European Journal 2016, 22 (45), 16103-16112.

Evora, A. O. L.;  Castro, R. A. E.;  Maria, T. M. R.;  Silva, M. R.;  ter Horst, J. H.;  Canotilho, J.; Eusebio, M. E. S., Co-crystals of diflunisal and isomeric pyridinecarboxamides - a thermodynamics and crystal engineering contribution. CrystEngComm 2016, 18, (25), 4749-4759.

Forsyth, C.;  Burns, I. S.;  Mulheran, P. A.; Sefcik, J., Scaling of Glycine Nucleation Kinetics with Shear Rate and Glass–Liquid Interfacial Area. Crystal Growth & Design 2016, 16 (1), 136-144.

Grothe, E.;  Meekes, H.;  Vlieg, E.;  ter Horst, J. H.; de Gelder, R., Solvates, Salts, and Cocrystals: A Proposal for a Feasible Classification System. Crystal Growth & Design 2016, 16, (6), 3237-3243.

Harrington, T. S., & Srai, J. S. , Understanding stages of supply network emergence in technology commercialisation. International Journal of Manufacturing Technology and Management 2016, 1,(1),1.

Harrington, T. S.;  Phillips, M. A.; Srai, J. S., Reconfiguring global pharmaceutical value networks through targeted technology interventions. International Journal of Production Research 2016, 55 (5), 1471-1487.

Javid, N.;  Kendall, T.;  Burns, I. S.; Sefcik, J., Filtration Suppresses Laser-Induced Nucleation of Glycine in Aqueous Solutions. Crystal Growth & Design 2016, 16 (8), 4196-4202.

Klapwijk, A. R.;  Simone, E.;  Nagy, Z. K.; Wilson, C. C., Tuning crystal morphology of succinic acid using a polymer additive. Crystal Growth & Design 2016, 16, (8), 4349-4359.

Marshall, R. J.;  Griffin, S. L.;  Wilson, C.; Forgan, R. S., Stereoselective Halogenation of Integral Unsaturated C-C Bonds in Chemically and Mechanically Robust Zr and Hf MOFs. Chemistry 2016, 22 (14), 4870-7.

Marshall, R. J.;  Hobday, C. L.;  Murphie, C. F.;  Griffin, S. L.;  Morrison, C. A.;  Moggach, S. A.; Forgan, R. S., Amino acids as highly efficient modulators for single crystals of zirconium and hafnium metal-organic frameworks. Journal of Materials Chemistry A 2016, 4 (18), 6955-6963.

Martinez-Marcos, L.;  Lamprou, D. A.;  McBurney, R. T.; Halbert, G. W., A novel hot-melt extrusion formulation of albendazole for increasing dissolution properties. International Journal of Pharmaceutics 2016, 499 (1–2), 175-185.

McLachlan, H.; Ni, X.-W., On the effect of added impurity on crystal purity of urea in an oscillatory baffled crystallizer and a stirred tank crystallizer. Journal of Crystal Growth 2016, 442, 81-88.

Ni, X.-W.; McLachlan, H., An Investigation into Parameters Affecting Crystal Purity of Urea in a Stirred Tank and an Oscillatory Baffled Crystallizer. Chemical Engineering Communications 2016, 203, (9), 1189-197.

Powell, K. A.;  Croker;  Rielly, C. D.; Nagy, Z. K., PAT-based design of agrochemical co-crystallization processes: A case-study for the selective crystallization of 1:1 and 3:2 co-crystals of p-Toluenesulfonamide/triphenylphosphine oxide. Chemical Engineering Science 2016, 152, 95-108.

Powell, K. A.;  Saleemi, A. N.;  Rielly, C. D.; Nagy, Z. K., Monitoring Continuous Crystallization of Paracetamol in the Presence of an Additive Using an Integrated PAT Array and Multivariate Methods. Organic Process Research & Development 2016. 20, (3), 626-636.

Robertson, K.;  Flandrin, P.-B.;  Klapwijk, A. R.; Wilson, C. C., Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC). Crystal Growth & Design 2016, 16 (8), 4759-4764.

Srai, J. S., Mukesh Kumar, Gary Graham, Wendy Phillips, James Tooze, Simon Ford, Paul Beecher, Baldev Raj, Mike Gregory, Manoj Kumar Tiwari, B. Ravi, Andy Neely, Ravi Shankar, Fiona Charnley & Ashutosh Tiwari, Distributed Manufacturing: scope, challenges and opportunities. Int. J. Production Research 2016, 54 (23), 6917-6935.

Srirambhatla, V. K.;  Guo, R.;  Price, S. L.; Florence, A. J., Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs. Chemical Communications 2016, 52, (46), 7384-7386.

Su, Q.;  Rielly, C. D.;  Powell, K. A.; Nagy, Z. K., Mathematical modelling and experimental validation of a novel periodic flow crystallization using MSMPR crystallizers. AIChE Journal 2016, 63, (4), 1313-1327.

Thomas, L. H.;  Wales, C.; Wilson, C. C., Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes. Chemical Communications 2016, 52 (46), 7372-7375.

Ward, M. R.;  Mackenzie, A. M.; Alexander, A. J., Role of Impurity Nanoparticles in Laser-Induced Nucleation of Ammonium Chloride. Crystal Growth & Design 2016. 16, (12), 6790-6796.

Wongpinyochit, T., Johnston, B. F., Seib, F. P., Manufacture and Drug Delivery Applications of Silk Nanoparticles. J. Vis. Exp. 2016, 116.

Yang, H.;  Yu, X.;  Raval, V.;  Makkawi, Y.; Florence, A., Effect of Oscillatory Flow on Nucleation Kinetics of Butyl Paraben. Crystal Growth & Design 2016, 16 (2), 875-886.


Badman, C.; Trout, B. L., Achieving continuous manufacturing. May 20-21, 2014 Continuous Manufacturing Symposium. J Pharm Sci 2015, 104 (3), 779-80.

Baxendale, I. R.;  Braatz, R. D.;  Hodnett, B. K.;  Jensen, K. F.;  Johnson, M. D.;  Sharratt, P.;  Sherlock, J. P.; Florence, A. J., Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium. J Pharm Sci 2015, 104 (3), 781-91.

Bhardwaj, R. M.;  Johnston, A.;  Johnston, B. F.; Florence, A. J., A random forest model for predicting the crystallisability of organic molecules. Crystengcomm 2015, 17 (23), 4272-4275.

Bhardwaj, R. M.;  Raval, V.;  Oswald, I. D.; Florence, A. J., Crystal structure of a mixed solvated form of amoxapine acetate. Acta Crystallogr E Crystallogr Commun 2015, 71 (Pt 2), 139-41.

Brandel, C.; ter Horst, J. H., Measuring induction times and crystal nucleation rates. Faraday Discuss 2015, 179 (0), 199-214.

Briggs, N. E. B.;  Schacht, U.;  Raval, V.;  McGlone, T.;  Sefcik, J.; Florence, A. J., Seeded Crystallization of β-l-Glutamic Acid in a Continuous Oscillatory Baffled Crystallizer. Organic Process Research & Development 2015, 19 (12), 1903-1911.

Brown, C. J.;  Adelakun, J. A.; Ni, X. W., Characterization and modelling of antisolvent crystallization of salicylic acid in a continuous oscillatory baffled crystallizer. Chem Eng Process 2015, 97, 180-186.

Hendon, C. H.;  Wittering, K. E.;  Chen, T. H.;  Kaveevivitchai, W.;  Popov, I.;  Butler, K. T.;  Wilson, C. C.;  Cruickshank, D. L.;  Miljanic, O. S.; Walsh, A., Absorbate-induced piezochromism in a porous molecular crystal. Nano Lett 2015, 15 (3), 2149-54.

Hunter, S.;  Coster, P. L.;  Davidson, A. J.;  Millar, D. I. A.;  Parker, S. F.;  Marshall, W. G.;  Smith, R. I.;  Morrison, C. A.; Pulham, C. R., High-Pressure Experimental and DFT-D Structural Studies of the Energetic Material FOX-7. J Phys Chem C 2015, 119 (5), 2322-2334.

Jawor-Baczynska, A.;  Moore, B. D.; Sefcik, J., Effect of mixing, concentration and temperature on the formation of mesostructured solutions and their role in the nucleation of DL-valine crystals. Faraday Discuss 2015, 179 (0), 141-54.

McGlone, T.;  Briggs, N. E. B.;  Clark, C. A.;  Brown, C. J.;  Sefcik, J.; Florence, A. J., Oscillatory Flow Reactors (OFRs) for Continuous Manufacturing and Crystallization. Organic Process Research & Development 2015, 19 (9), 1186-1202.

Powell, K. A.;  Bartolini, G.;  Wittering, K. E.;  Saleemi, A. N.;  Wilson, C. C.;  Rielly, C. D.; Nagy, Z. K., Toward Continuous Crystallization of Urea-Barbituric Acid: A Polymorphic Co-Crystal System. Crystal Growth & Design 2015, 15 (10), 4821-4836.

Powell, K. A.;  Saleemi, A. N.;  Rielly, C. D.; Nagy, Z. K., Periodic steady-state flow crystallization of a pharmaceutical drug using MSMPR operation. Chem Eng Process 2015, 97 (0), 195-212.

Reus, M. A.;  van der Heijden, A. E. D. M.; ter Horst, J. H., Solubility Determination from Clear Points upon Solvent Addition. Organic Process Research & Development 2015, 19 (8), 1004-1011.

Sans, V.;  Porwol, L.;  Dragone, V.; Cronin, L., A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy. Chem Sci 2015, 6 (2), 1258-1264.

Sayin, R.;  Martinez-Marcos, L.;  Osorio, J. G.;  Cruise, P.;  Jones, I.;  Halbert, G. W.;  Lamprou, D. A.; Litster, J. D., Investigation of an 11mm diameter twin screw granulator: Screw element performance and in-line monitoring via image analysis. Int J Pharm 2015, 496 (1), 24-32.

Siddique, H.;  Brown, C. J.;  Houson, I.; Florence, A. J., Establishment of a Continuous Sonocrystallization Process for Lactose in an Oscillatory Baffled Crystallizer. Organic Process Research & Development 2015, 19 (12), 1871-1881.

Srai, J. S.;  Badman, C.;  Krumme, M.;  Futran, M.; Johnston, C., Future supply chains enabled by continuous processing--opportunities and challenges. May 20-21, 2014 Continuous Manufacturing Symposium. J Pharm Sci 2015, 104 (3), 840-9.

Srai, J. S.;  Harrington, T.;  Alinaghian, L.; Phillips, M., Evaluating the potential for the continuous processing of pharmaceutical products-a supply network perspective. Chem Eng Process 2015, 97, 248-258.

Su, Q. L.;  Benyahia, B.;  Nagy, Z. K.; Rielly, C. D., Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations. Organic Process Research & Development 2015, 19 (12), 1859-1870.

Su, Q. L.;  Nagy, Z. K.; Rielly, C. D., Pharmaceutical crystallisation processes from batch to continuous operation using MSMPR stages: Modelling, design, and control. Chem Eng Process 2015, 89 (0), 41-53.

Sun, C. C.;  Sun, W.;  Price, S.;  Hughes, C.;  Ter Horst, J.;  Veesler, S.;  Lewtas, K.;  Myerson, A.;  Pan, H.;  Coquerel, G.;  van den Ende, J.;  Meekes, H.;  Mazzotti, M.;  Rosbottom, I.;  Taulelle, F.;  Black, S.;  Mackenzie, A.;  Janbon, S.;  Vekilov, P.;  Threlfall, T.;  Turner, T.;  Back, K.;  Cuppen, H.;  Toroz, D.;  Sefcik, J.;  Lovelock, J.;  Hammond, R.;  Candoni, N.;  Simone, E.;  Ward, M.;  Bertran, C. A.;  Vetter, T.;  Sear, R.;  De Yoreo, J.;  Davey, R.;  Anwar, J.;  Santiso, E.;  Wu, D. T.;  Roberts, K.;  Peters, B.;  Schroeder, S.;  Jones, F.;  Rasmuson, A.;  Colfen, H.;  Zeglinski, J.; Salvalaglio, M., Solvent and additive interactions as determinants in the nucleation pathway: general discussion. Faraday Discuss 2015, 179 (0), 383-420.

Sun, W.;  Booth, S.;  Myerson, A.;  Hughes, C.;  Pan, H.;  Coquerel, G.;  Brandel, C.;  Meekes, H.;  Mazzotti, M.;  Fabian, L.;  Black, S.;  Vekilov, P.;  Back, K.;  Toroz, D.;  Lovelock, J.;  Sefcik, J.;  Rasmuson, A.;  Breynaert, E.;  Sear, R.;  Hammond, R.;  Ward, M.;  Threlfall, T.;  De Yoreo, J.;  Davey, R.;  Ristic, R.;  Lewtas, K.;  Roberts, K.;  Hare, A.;  Gich, M.;  Colfen, H.;  Likhatskiy, M.;  ter Horst, J.; Sommerdijk, N., Time and space resolved methods: general discussion. Faraday Discuss 2015, 179 (0), 247-67.

Tachtatzis, C.;  Sheridan, R.;  Michie, C.;  Atkinson, R. C.;  Cleary, A.;  Dziewierz, J.;  Andonovic, I.;  Briggs, N. E. B.;  Florence, A. J.; Sefcik, J., Image-based monitoring for early detection of fouling in crystallisation processes. Chem Eng Sci 2015, 133, 82-90.

ter Horst, J. H.;  Schmidt, C.; Ulrich, J., Fundamentals of Industrial Crystallization. In Handbook of Crystal Growth, Rudolph, P., Ed. Elsevier: Boston, 2015; pp 1317-1349.

Ward, M. R.;  Jamieson, W. J.;  Leckey, C. A.; Alexander, A. J., Laser-induced nucleation of carbon dioxide bubbles. J Chem Phys 2015, 142 (14), 144501.

Ward, M. R.;  Rae, A.; Alexander, A. J., Nonphotochemical Laser-Induced Crystal Nucleation by an Evanescent Wave. Crystal Growth & Design 2015, 15 (9), 4600-4605.

Wittering, K. E.;  Agnew, L. R.;  Klapwijk, A. R.;  Robertson, K.;  Cousen, A. J. P.;  Cruickshank, D. L.; Wilson, C. C., Crystallisation and physicochemical property characterisation of conformationally-locked co-crystals of fenamic acid derivatives. Crystengcomm 2015, 17 (19), 3610-3618.

Wongpinyochit, T.;  Uhlmann, P.;  Urquhart, A. J.; Seib, F. P., PEGylated Silk Nanoparticles for Anticancer Drug Delivery. Biomacromolecules 2015, 16 (11), 3712-22.


Arlin, J. B.;  Bhardwaj, R. M.;  Johnston, A.;  Miller, G. J.;  Bardin, J.;  MacDougall, F.;  Fernandes, P.;  Shankland, K.;  David, W. I. F.; Florence, A. J., Structure and stability of two polymorphs of creatine and its monohydrate. Crystengcomm 2014, 16 (35), 8197-8204.

Brown, C. J.;  Lee, Y. C.;  Nagy, Z. K.; Ni, X., Evaluation of crystallization kinetics of adipic acid in an oscillatory baffled crystallizer. Crystengcomm 2014, 16 (34), 8008-8014. 

Callahan, C. J.; Ni, X. W., An investigation into the effect of mixing on the secondary nucleation of sodium chlorate in a stirred tank and an oscillatory baffled crystallizer. Crystengcomm 2014, 16 (4), 690-697.

Delori, A.;  Maclure, P.;  Bhardwaj, R. M.;  Johnston, A.;  Florence, A. J.;  Sutcliffe, O. B.; Oswald, I. D. H., Drug solid solutions - a method for tuning phase transformations. Crystengcomm 2014, 16 (26), 5827-5831.

Etherson, K.;  Halbert, G.; Elliott, M., Determination of excipient based solubility increases using the CheqSol method. Int J Pharm 2014, 465 (1-2), 202-9.

McKellar, S. C.;  Kennedy, A. R.;  McCloy, N. C.;  McBride, E.; Florence, A. J., Formulation of Liquid Propofol as a Cocrystalline Solid. Crystal Growth & Design 2014, 14 (5), 2422-2430.

Pulham, C. R., Editorial. CrystEngComm 2014, 16 (26), 5752-5752.

Srai, J. S., Harrington, T.S., Alinaghian, L., An approach to exploring integration benefits of continuous flow technologies within Pharmaceutical supply chains. Chemistry Today 2014, 32 (SUPPLEMENT - CROS CMOS), P. 27-34. 

Srai, J. S., Christodoulou, P., Harrington, T.S., Capturing value from global networks: strategic approaches to configuring production, supply and service networks. IfM University of Cambridge 2014, 38-51. ISSN:  978-1-902546-30-8

Srai, J. S., Twenty-first supply chains - transforming the pharmaceutical industry. IfM Review 2014, 1, 17-19.

Thomas, L. H.;  Klapwijk, A. R.;  Wales, C.; Wilson, C. C., Intermolecular hydrogen transfer and solubility tuning in multi-component molecular crystals of the API piroxicam. Crystengcomm 2014, 16 (26), 5924-5932.

Wittering, K.;  King, J.;  Thomas, L. H.; Wilson, C. C., From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid. Crystals 2014, 4 (2), 123-140.

Zhao, L.;  Raval, V.;  Briggs, N. E. B.;  Bhardwaj, R. M.;  McGlone, T.;  Oswald, I. D. H.; Florence, A. J., From discovery to scale-up: α-lipoic acid : nicotinamide co-crystals in a continuous oscillatory baffled crystalliser. CrystEngComm 2014, 16 (26), 5769-5780.


Bhardwaj, R. M.; Florence, A. J., 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno [2, 3-b][1, 5] benzodiazepine (olanzapine) propan-2-ol disolvate. Acta Crystallographica Section E: Structure Reports Online 2013, 69 (5), o752-o753. ISSN: 1600-5368

Bhardwaj, R. M.;  Johnston, B. F.;  Oswald, I. D.; Florence, A. J., A complementary experimental and computational study of loxapine succinate and its monohydrate. Acta Crystallogr C 2013, 69 (Pt 11), 1273-8.

Bhardwaj, R. M.;  Price, L. S.;  Price, S. L.;  Reutzel-Edens, S. M.;  Miller, G. J.;  Oswald, I. D. H.;  Johnston, B. F.; Florence, A. J., Exploring the Experimental and Computed Crystal Energy Landscape of Olanzapine. Crystal Growth & Design 2013, 13 (4), 1602-1617.

Braun, D. E.;  Bhardwaj, R. M.;  Arlin, J. B.;  Florence, A. J.;  Kahlenberg, V.;  Griesser, U. J.;  Tocher, D. A.; Price, S. L., Absorbing a Little Water: The Structural, Thermodynamic, and Kinetic Relationship between Pyrogallol and Its Tetarto-Hydrate. Cryst Growth Des 2013, 13 (9), 4071-4083.

Dragone, V.;  Sans, V.;  Rosnes, M. H.;  Kitson, P. J.; Cronin, L., 3D-printed devices for continuous-flow organic chemistry. Beilstein J Org Chem 2013, 9, 951-9.

Hamilton, P.;  Littlejohn, D.;  Nordon, A.;  Sefcik, J.;  Slavin, P.;  Andrews, J.; Dallin, P., Investigation of factors affecting isolation of needle-shaped particles in a vacuum-agitated filter drier through non-invasive measurements by Raman spectrometry. Chem Eng Sci 2013, 101, 878-885.

Jawor-Baczynska, A.;  Moore, B. D.;  Lee, H. S.;  McCormick, A. V.; Sefcik, J., Population and size distribution of solute-rich mesospecies within mesostructured aqueous amino acid solutions. Faraday Discuss 2013, 167, 425-40.

Jawor-Baczynska, A.;  Sefcik, J.; Moore, B. D., 250 nm Glycine-Rich Nanodroplets Are Formed on Dissolution of Glycine Crystals But Are Too Small To Provide Productive Nucleation Sites. Crystal Growth & Design 2013, 13 (2), 470-478.

Kitson, P. J.;  Symes, M. D.;  Dragone, V.; Cronin, L., Combining 3D printing and liquid handling to produce user-friendly reactionware for chemical synthesis and purification. Chemical Science 2013, 4 (8), 3099-3103.

Manninen, M.;  Gorshkova, E.;  Immonen, K.; Ni, X. W., Evaluation of axial dispersion and mixing performance in oscillatory baffled reactors using CFD. J Chem Technol Biot 2013, 88 (4), 553-562.

Vitórica-Yrezábal, I. J.;  Mínguez Espallargas, G.;  Soleimannejad, J.;  Florence, A. J.;  Fletcher, A. J.; Brammer, L., Chemical transformations of a crystalline coordination polymer: a multi-stage solid–vapour reaction manifold. Chemical Science 2013, 4 (2), 696-708.

Ward, M. R.;  Botchway, S. W.;  Ward, A. D.; Alexander, A. J., Second-harmonic scattering in aqueous urea solutions: evidence for solute clusters? Faraday Discuss 2013, 167 (0), 441-54.


Bhardwaj, R. M.;  Oswald, I.; Florence, A. J., 6-Methyl-1,3,5-triazine-2,4-diamine butane-1,4-diol monosolvate. Acta Crystallogr Sect E Struct Rep Online 2012, 68 (Pt 12), o3377.

Braun, D. E.;  Bhardwaj, R. M.;  Florence, A. J.;  Tocher, D. A.; Price, S. L., Complex Polymorphic System of Gallic Acid-Five Monohydrates, Three Anhydrates, and over 20 Solvates. Cryst Growth Des 2013, 13 (1), 19-23.

Brown, C. J.; Ni, X. W., Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer. Crystengcomm 2012, 14 (8), 2944-2949.  

Callahan, C. J.; Ni, X. W., Probing into Nucleation Mechanisms of Cooling Crystallization of Sodium Chlorate in a Stirred Tank Crystallizer and an Oscillatory Baffled Crystallizer. Crystal Growth & Design 2012, 12 (5), 2525-2532.

de la Oliva, A. R.;  Sans, V.;  Miras, H. N.;  Yan, J.;  Zang, H.;  Richmond, C. J.;  Long, D. L.; Cronin, L., Assembly of a gigantic polyoxometalate cluster {W200Co8O660} in a networked reactor system. Angew Chem Int Ed Engl 2012, 51 (51), 12759-62.

Hamilton, P.;  Littlejohn, D.;  Nordon, A.;  Sefcik, J.; Slavin, P., Validity of particle size analysis techniques for measurement of the attrition that occurs during vacuum agitated powder drying of needle-shaped particles. Analyst 2012, 137 (1), 118-25.

Harrington, T. S., Kirkwood, D.A. & Srai, J. S., Performance Metric Selection Methodology for Multi- Organizational Service Network Integration. The Journal of Applied Management and Entrepreneurship 2012, 17 (3), 30-35. Performance Metric Selection Methodology for Multi-Organizational Service Network Integration — University of East Anglia (

Harrington, T. S.; Srai, J. S., Defining product-service network configurations and location roles: a current and future state analysis framework for international engineering operations. International Journal of Product Development 2012, 17 (3/4), 228-253.

Kitson, P. J.;  Rosnes, M. H.;  Sans, V.;  Dragone, V.; Cronin, L., Configurable 3D-Printed millifluidic and microfluidic 'lab on a chip' reactionware devices. Lab Chip 2012, 12 (18), 3267-71.

McKellar, S. C.;  Urquhart, A. J.;  Lamprou, D. A.; Florence, A. J., Polymer templating of supercooled indomethacin for polymorph selection. ACS Comb Sci 2012, 14 (3), 155-9.

Richmond, C. J.;  Miras, H. N.;  de la Oliva, A. R.;  Zang, H.;  Sans, V.;  Paramonov, L.;  Makatsoris, C.;  Inglis, R.;  Brechin, E. K.;  Long, D. L.; Cronin, L., A flow-system array for the discovery and scale up of inorganic clusters. Nat Chem 2012, 4 (12), 1037-43.

Saleemi, A. N.;  Rielly, C. D.; Nagy, Z. K., Comparative Investigation of Supersaturation and Automated Direct Nucleation Control of Crystal Size Distributions using ATR-UV/vis Spectroscopy and FBRM. Crystal Growth & Design 2012, 12 (4), 1792-1807.

Saleemi, A. N.;  Rielly, C. D.; Nagy, Z. K., Monitoring of the combined cooling and antisolvent crystallisation of mixtures of aminobenzoic acid isomers using ATR-UV/vis spectroscopy and FBRM. Chem Eng Sci 2012, 77, 122-129.


Arlin, J. B.;  Florence, A. J.;  Johnston, A.;  Kennedy, A. R.;  Miller, G. J.; Patterson, K., Systematic Data Set for Structure-Property Investigations: Solubility and Solid-State Structure of Alkaline Earth Metal Salts of Benzoates. Crystal Growth & Design 2011, 11 (4), 1318-1327.

Arlin, J. B.;  Price, L. S.;  Price, S. L.; Florence, A. J., A strategy for producing predicted polymorphs: catemeric carbamazepine form V. Chem Commun (Camb) 2011, 47 (25), 7074-6.

Brown, C. J.; Ni, X. W., Online Evaluation of Paracetamol Antisolvent Crystallization Growth Rate with Video Imaging in an Oscillatory Baffled Crystallizer. Crystal Growth & Design 2011, 11 (3), 719-725.

Brown, C. J.; Ni, X. W., Evaluation of Growth Kinetics of Antisolvent Crystallization of Paracetamol in an Oscillatory Baffled Crystallizer Utilizing Video Imaging. Crystal Growth & Design 2011, 11 (9), 3994-4000.