Welcome to CMAC News. If you have any news items for the next edition please contact helen.feilden@strath.ac.uk 



CMAC White Papers Now Available Online

The White Papers from the International Symposium on Continuous Manufacturing of Pharmaceuticals have now been published in the Journal of Pharmaceutical Sciences Volume 104 - March 2015 Special Topic Commentaries on Continuous Manufacturing. 

Download now 




First Minister Meets CMAC at TIC Celebration

Scotland's First Minister Nicola Sturgeon attended the TIC Soft Opening Celebration event in December and was delighted to meet some of our CMAC researchers. Hosted by the Principle, Professor Sir Jim McDonald the event provided its occupants with a sneak peek inside Scotland’s world leading Technology Innovation Centre.

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CMAC Shortlisted for Innovation Award 2015

CMAC were nominated and shortlisted for a Scottish Enterprise Life Sciences Award in the ‘Innovation Award’ category. With three shortlisted finalists in each category, selected by the judging panel, the winners were announced at the Scottish Life Sciences Annual Dinner in February 2015. The awards are presented to recognise excellence in companies and individuals who are making a significant contribution to the industry.

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CMAC Innovations in Continuous Work-up Workshop

On Wednesday 18 March, twenty five industrialists, academics and interested parties form CPI and the KTN attended a workshop to showcase the 6 iCON projects funded by the EPSRC National Centre. The iCON projects were conceived to stimulate research and interest in areas that are not currently active in the CMAC research programme but are key to driving the uptake of continuous processing.

The morning comprised 6 stimulating presentations from Frans Muller (University of Leeds), Alexei Lapkin Cambridge University), Svetlana Ignatova Brunel University), Paulo Filliponi (Ian Baxendale group, University of Durham), Andrea Rayat and Mike Hoare (UCL), Eric Sliwinski (Steve Ley group, Cambridge University). The afternoon was spent assessing the current landscape identifying key gaps, areas requiring continual improvement and other groups/companies who are active in this area. There was also time for networking and detailed 1:1 discussions.

Next steps: CMAC will collate the output and prepare a short report to be shared with attendees and any other interested parties and use this to drive and influence funders in this under-researched area.

CMAC Mentor Group Meetings

All of the mentor groups are now up and running having had at least 1 meeting with face-to-face meetings either held or booked in the next month. Two face-to-face meetings have been held:

Controlling Growth and Morphology mentor group held at Bath University: with 3 industrialists from GSK and AZ with researchers from Heriot Watt, Edinburgh and Bath we met on a sunny February for a very stimulating  day of discussion, presentations and a really interesting tour of the labs looking at the novel small scale continuous crystallisation equipment that is being developed there.

Nucleation mentor group at the University of Edinburgh: On Thursday 19 March, 11 of us met at Edinburgh University to discuss the work that is ongoing in CMAC in the NPLIN and secondary nucleation area. With presentations from the Pulham, Sefcik and Alexander group researchers it was full day of valuable discussion and a live demonstration of NPLIN. Input and presentations from industrialists from GSK and AZ gave in insight into their careers, interests and really highlighted the fact that even though our aim is to work in a continuous environment, much of the work is directly applicable in their daily jobs and to batch processes as well.

The industrial mentor groups have seen a large growth in the last year and this summer will comprise ~50PhD students, 13 PDRAs, 12 academics and 31 industrial mentors.


CMAC Are Moving to TIC 

CMAC will move into the new Technology and Innovation Centre (TIC) at the University of Strathclyde in late March 2015. The move into the new labs in TIC will establish the new National Facility for Continuous Manufacturing & Crystallisation Research for Pharmaceutical Products. The National Facility will offer the continuous manufacturing research community and external parties / SMEs the chance to use our new state of the art research facilities. 

It is anticipated that by mid-April the vast majority of research will resume in the new world-class facility. Additional space has been allocated to CMAC within TIC on Level 6and will accommodate the process development lab, X-ray suite and TOF-SIMS lab and requires fit-out works to make it fit for purpose. On level 1 we will have surface analysis facilities. 

We are pleased to announce that as a result of equipment revisions on the RPIF Award and a detailed space planning exercise, CMAC will now house all secondary processing equipment on level 8 within TIC, which will allow a seamless transition between primary and secondary processing activities. 



CMAC National Facility Progress

Awarded by the Higher Education Funding Council for England (HEFCE)'s UK Research Partnership Investment Fund (UKRPIF) CMAC received £11.4M cash and supported with £22.8m industry and charity contributions. The award is funding the purchase of equipment to fit out the National Facility for Continuous Manufacturing & Crystallisation Research for Pharmaceutical Products and staff to support this. Nina Denver and Thomas Ball, who have both recently joined CMAC as Technicians, will support the lab manager in preparation and implementation of the move to TIC. The last major tender to be awarded is concentrated on expanding our capability in the X-ray suite. An X-ray Nano-CT instrument will allow us to non-destructively visualise inside a variety of objects, be it inhalers, tablets or crystals. New X-ray diffraction instruments will aid our understanding of crystal structure and powder analysis.

CMAC will have an extensive capability in the areas of primary and secondary processing, process analytical technologies (PAT), spectroscopy, imaging, size and shape analysis, X-ray diffraction, and physical properties characterisation. Our new website and promotional material will highlight the available instruments and the capability offered. 









Press Highlights


Clive Badman, Industrial Chairman of CMAC, Article in Scotsman

CMAC (Continuous Manufacturing and Crystallisation) featured in the Scotsman with an article about Clive Badman, Industrial Chairman of CMAC. The article describes how CMAC is at the forefront of research into changing the way pharmaceuticals are manufactured. 

To view the article, please follow this link.



Talent Pipeline

Project Manager App A REMEDIES - John Mulgrew

John joined CMAC as Project Manager for technology application projects, focusing on continuous manufacturing of APIs with large pharma, contract manufacturing organisations and technology companies.  John provides support for our Industry Director and management expertise to support AMSCI AppA.  His industrial career spans 20 years, working as an engineering and capital project management consultant for companies such as Amgen, J&J McNeil, Baxter Healthcare, Merck, Wyeth (Pfizer), Shire, Talecris, Tengion and most recently as Manager, Facilities and Project Engineering at Integra Life Science.

Email: john.mulgrew@strath.ac.uk






Senior Research Fellow App B REMEDIES - Dr John Robertson 

John joined CMAC in September 2014 and  has a background in novel technology development for pharmaceutical applications. Currently, John is supporting the development of capability in the secondary pharmaceutical processing area. He previously worked for GlaxoSmithKline for 16 years in a number of technical roles including development of continuous secondary processing, particle engineering, drug delivery and SCF technologies. John is a Chartered Chemical Engineer, originally studying Engineering at Strathclyde and then moving to Birmingham to undertake a PhD with SmithKline Beecham,  followed by an industrially funded post doctorate position. His areas of interest are in solids processing, formulation and particle design. John also teaches process engineering for apprentices in the pharmaceutical industry.




PDRA Sefcik Group University of Strathclyde – Dr Pol MacFhionnghaile 

Dr Pol MacFhionnghaile joined CMAC in Jan Sefcik’s group as a research associate in February 2015.  Previous to this he worked in AbbVie (formally Abbott) as a Process Chemist looking at statistical methods to better understand some processes. Before that he worked as a teacher in the Centre for Talented Youth where he taught children physics, chemistry, and maths. Pol graduated from the National University of Ireland, Galway with a PhD in using chemometrics coupled with analytical techniques to investigate solid state changes of sulfa-drugs.

E-mail: pol.macfhionnghaile@strath.ac.uk


Next Steps

PDRA in the Sefcik group at Strathclyde, Anna Jawor-Baczynska left CMAC in January 2015 to take up employment with AstraZeneca in Macclesfield, UK. 





Research Associate (15464)

Strathclyde Institute of Pharmacy and Biomedical Sciences 

Faculty Faculty of Science 
Department/School Strathclyde Institute of Pharmacy and Biomedical Sciences 
Staff Category Research 
Type of Employment Fixed-term 
Working Hours Full-time
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PhD Studentships in International Doctoral Training Centre, 2015 Start

PhD Studentships in the International Doctoral Training Centre in Continuous Manufacturing and Crystallisation of Pharmaceuticals that is aligned with CMAC are now available for a 2015 Start. 
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MSc Advanced Pharmaceutical Manufacturing, 2015 Start

Full tuition fee awards available in our unique MSc Advanced Pharmaceutical Manufacturing course at the University of Strathclyde. The bespoke course is designed to produce highly-skilled graduates in continuous manufacturing science and technology to meet the growing demands for expertise in this area.
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Recruiting Soon in CMAC:

2 Research Associates and 1 Project Manager

Keep an eye on the CMAC Vacancies for details! We also advertise industrial positions for our key partners.


AstraZeneca Senior Scientist - PAT

Reference Number: GMD173 
Career Area: Pharmaceutical Development 
Date Added: 30/01/2015 
Location(s): North West (Macclesfield)

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CMAC participation in British Council Workshop, Novosibirsk, Siberia

From 9-13th February 2015 Dr Thomas McGlone, (CMAC  PDRA, University of  Strathclyde),  Dr Karen Robertson (CMAC PDRA, University of Bath) and Adam Michalchuk (DTC, University of Edinburgh) attended ‘Molecular Materials – from fundamentals to applications’ in Novosibirsk, Siberia.

This early career researcher scientific workshop was sponsored by the British Council and the RSC and was co-organised by CMAC’s PI Prof. Colin Pulham and Prof. Elena Boldyreva (Novosibirsk University). 

Esteemed colleagues in our field including Prof. Sally Price (CPOSS), Prof Joel Bernstein and Prof Bill Jones (CMAC Advisory Board) were in attendance. Find out more here





Awards and prizes

Dr Thomas McGlone CMAC  PDRA, University of  Strathclyde, recently secured a place on a European Young Chemists Networks scheme called ‘Young Chemists Crossing Borders’. The scheme includes attendance and  a presentation at the 250th ACS conference in Boston (August 2015) in addition to visits to MIT, Harvard, Novartis and Genzyme. 


Jo Lothian, a researcher in Alison Nordon’s group at Strathclyde went on secondment to GSK at the end of 2014. The 4-month project included work using Eyecon imaging equipment to monitor Twin Screw Granulation processes. Jo won a GSK initiative award at GSK for solving fouling issues on her project.  




Badman, C.; Trout, B. L., Achieving continuous manufacturing. May 20-21, 2014 continuous manufacturing symposium. Journal of pharmaceutical sciences 2015, 104 DOI: 10.1002/jps.24246  

Baxendale, I. R.; Braatz, R. D.; Hodnett, B. K.; Jensen, K. F.; Johnson, M. D.; Sharratt, P.; Sherlock, J. P.; Florence, A. J., Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 continuous manufacturing symposium. Journal of pharmaceutical sciences 2015, 104 (3), 781-91 DOI: 10.1002/jps.24252 

Bhardwaj, R. M.; Johnston, A.; Johnston, B.; Florence, A. J., A Random Forest Model for Predicting the Crystallisability of Organic Molecules. CrystEngComm 2015 DOI: 10.1039/C4CE02403F  

Srai, J. S.; Badman, C.; Krumme, M.; Futran, M.; Johnston, C., Future supply chains enabled by continuous processing-opportunities and challenges. May 20-21, 2014 continuous manufacturing symposium. Journal of pharmaceutical sciences 2015, 104 (3), 840-9 DOI: 10.1002/jps.24343  

Yang, H., Relation between metastable zone width and induction time of butyl paraben in ethanol. CrystEngComm 2015, 17, 577-586 DOI: 10.1039/C4CE01625D  


Other Articles

Elanor Brammer, Fraser Mabbott, Laura Martinez-Marcos, Rajni M. Bhardwaj  have  published an article at the UKICRS Newsletter 2014 “Continuous Manufacturing – A paradigm shift in the Pharmaceutical Industry” p29-32 link   



Dates For The Diary 

CMAC Events

CMAC Annual Open Day 23rd - 24th September 2015 at University of Strathclyde.


CMAC Seminar Programme 

29th April 2015 - Dr Harris (Charalampos) Makatsoris, Brunel University 

26th May 2015 - Professor Chris Frampton, Brunel University 

18th June 2015 - Professor Claire S. Adjiman, Imperial College


Come and See Us at These Events

APS Particle Engineering - Joint Meeting with SSPC

Venue: Trinity College, Dublin

13th and 14th April 2015

Find out more here


2015 UKICRS Workshop & Symposium, University of Nottingham

16th and 17th April 2015

The symposium is aimed at those working in the pharmaceutical sciences. As always, the symposium will offer a wide range of opportunities for both young and established scientists to present their latest research and network with others from academia and industry.

Find out more here.


Bruker Scanning Probe Microscopy Conference & User Meeting 2015

22nd and 23rd April 2015 at the University of Strathclyde.

The conference is been organized in collaboration with CMAC National Facility.

CMAC Academic Director, Professor Alastair Florence will open the meeting. CMAC Academic, Dr Dimitrios Lamprou is on the organising committee and will also give an oral presentation and chair a session. 


Nucleation - A Transition State to the Directed Assembly of Materials

30th April - 1st May 2015, Leeds UK.

Find out more here 


Making Molecules to Make Materials – An ECR Event

19th – 20th May 2015

Weetwood Hall Conference Centre & Hotel, Leeds

Find out more here


First International Convention IMMUNOPHARMACOLOGY - VACCIPHARMA 2015

14th - 19th June 2015  at Varadero-Cuba 

CMAC Academic, Dr Dimitrios Lamprou been invited to give two oral presentations. 

Find out more here 


ACHEMA – World Forum. Leading Show for the Process Industries

15th - 19th  June 2015 - Frankfurt am Main, Germany

Our CMAC Industry Director and Technical Project Manager will be at this event.

Find out more here 


BACG - 46th Annual Conference

21st - 23rd June 2015 at Queen Mary University of London, UK.


If you have any questions or would like further information, please contact the conference organizers (bacg2015@qmul.ac.uk). 


Summer School on Crystal Shape Engineering

6th - 10th July 2015

ETH Zurich

Zurich, Switzerland

Find out more here Summer School on Crystal Shape Engineering 


42nd Annual Meeting & Exposition of the Controlled Release Society

The 42nd Annual Meeting & Exposition of the Controlled Release Society, 26th -29th July 2015 at Edinburgh International Conference Centre

CMAC Academic Dr Dimitrios Lamprou will chair a session and also there will be poster presentations from CMAC Post-Docs and PhD students.

Find out more here


APS International PharmSci 2015

7th - 9th September 2015 at East Midlands Conference Centre in Nottingham.

CMAC Academic Dr Dimitrios Lamprou will chair a session and also will be poster and oral presentations from many CMAC Post-Docs and PhD students.

Find out more here.


4th Annual EPSRC Manufacturing the Future Conference

Please save the date 17th September 2015 for the 2015 conference, which will be hosted by the Institute for Manufacturing, University of Cambridge.

The conference will be held at Churchill College, with evening events at Jesus College and the Imperial War Museum, Duxford. Further information will be available online shortly.

Contact: ifm-events@eng.cam.ac.uk


20th Larson Workshop October

4th - 7th October 2015.  The Bellevue in Philadelphia, PA.

http://www.extension.iastate .edu/registration/events/conferences/crystallization/    

Brochure here




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